Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912306803> ?p ?o ?g. }
- W2912306803 endingPage "595" @default.
- W2912306803 startingPage "589" @default.
- W2912306803 abstract "Abstract Lipid mediators, such as prostanoids and leukotrienes (LTs), exert a range of actions through their own receptors on cell surfaces in various pathophysiological conditions. It has been reported that the production of prostanoids and LTs is significantly elevated in the skin lesions of some chronic inflammatory skin diseases, such as atopic dermatitis (AD) and psoriasis, showing the possible involvement of these lipid mediators in the development of those diseases. Although the actual significance of these lipid mediators in humans is still unclear, the findings from studies in mice suggest diverse roles of the lipid mediators in the progression or regulation of these diseases. For example, in a mouse AD model, prostaglandin D2 inhibits the induction of Th2 cells through DP receptor on Langerhans cells, while it promotes infiltration of Th2 cells through chemoattractant receptor-homologous molecule expressed on Th2 cells. In a psoriasis model, thromboxane A2-TP signaling promotes psoriatic dermatitis by facilitating IL-17 production from γδ T cells. In this short review, we summarize the current findings on the roles of prostanoids and LTs in AD and psoriasis as revealed by studies in mice, and discuss the potential of these lipid mediators as therapeutic targets in humans." @default.
- W2912306803 created "2019-02-21" @default.
- W2912306803 creator A5019730291 @default.
- W2912306803 creator A5023533946 @default.
- W2912306803 date "2019-02-03" @default.
- W2912306803 modified "2023-10-17" @default.
- W2912306803 title "Prostanoids and leukotrienes in the pathophysiology of atopic dermatitis and psoriasis" @default.
- W2912306803 cites W1493450972 @default.
- W2912306803 cites W1663045307 @default.
- W2912306803 cites W1939997832 @default.
- W2912306803 cites W1963790971 @default.
- W2912306803 cites W1965052798 @default.
- W2912306803 cites W1983754832 @default.
- W2912306803 cites W1986161286 @default.
- W2912306803 cites W1991225939 @default.
- W2912306803 cites W2007940860 @default.
- W2912306803 cites W2009676263 @default.
- W2912306803 cites W2012097026 @default.
- W2912306803 cites W2012770902 @default.
- W2912306803 cites W2029473902 @default.
- W2912306803 cites W2030248217 @default.
- W2912306803 cites W2030375512 @default.
- W2912306803 cites W2030634089 @default.
- W2912306803 cites W2034452985 @default.
- W2912306803 cites W2034971573 @default.
- W2912306803 cites W2042860739 @default.
- W2912306803 cites W2043249117 @default.
- W2912306803 cites W2056921894 @default.
- W2912306803 cites W2057098942 @default.
- W2912306803 cites W2071957045 @default.
- W2912306803 cites W2077436122 @default.
- W2912306803 cites W2078002134 @default.
- W2912306803 cites W2087178163 @default.
- W2912306803 cites W2088444832 @default.
- W2912306803 cites W2092750645 @default.
- W2912306803 cites W2093929406 @default.
- W2912306803 cites W2096279219 @default.
- W2912306803 cites W2106162247 @default.
- W2912306803 cites W2114504347 @default.
- W2912306803 cites W2115111224 @default.
- W2912306803 cites W2121612337 @default.
- W2912306803 cites W2138364128 @default.
- W2912306803 cites W2142849884 @default.
- W2912306803 cites W2145434484 @default.
- W2912306803 cites W2158259619 @default.
- W2912306803 cites W2163744692 @default.
- W2912306803 cites W2166893697 @default.
- W2912306803 cites W2171749585 @default.
- W2912306803 cites W2331503091 @default.
- W2912306803 cites W2341950055 @default.
- W2912306803 cites W2412442244 @default.
- W2912306803 cites W2438455430 @default.
- W2912306803 cites W2560807687 @default.
- W2912306803 cites W2561759163 @default.
- W2912306803 cites W2576968561 @default.
- W2912306803 cites W2593200577 @default.
- W2912306803 cites W2610814011 @default.
- W2912306803 cites W2615030262 @default.
- W2912306803 cites W2620810313 @default.
- W2912306803 cites W2752127863 @default.
- W2912306803 cites W2752706812 @default.
- W2912306803 cites W2752721387 @default.
- W2912306803 cites W2763327918 @default.
- W2912306803 cites W2771977002 @default.
- W2912306803 cites W2778331448 @default.
- W2912306803 cites W2783616522 @default.
- W2912306803 cites W2792361226 @default.
- W2912306803 cites W2799542971 @default.
- W2912306803 cites W2885712658 @default.
- W2912306803 cites W4211026773 @default.
- W2912306803 cites W4211077900 @default.
- W2912306803 doi "https://doi.org/10.1093/intimm/dxy087" @default.
- W2912306803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30715370" @default.
- W2912306803 hasPublicationYear "2019" @default.
- W2912306803 type Work @default.
- W2912306803 sameAs 2912306803 @default.
- W2912306803 citedByCount "40" @default.
- W2912306803 countsByYear W29123068032019 @default.
- W2912306803 countsByYear W29123068032020 @default.
- W2912306803 countsByYear W29123068032021 @default.
- W2912306803 countsByYear W29123068032022 @default.
- W2912306803 countsByYear W29123068032023 @default.
- W2912306803 crossrefType "journal-article" @default.
- W2912306803 hasAuthorship W2912306803A5019730291 @default.
- W2912306803 hasAuthorship W2912306803A5023533946 @default.
- W2912306803 hasBestOaLocation W29123068031 @default.
- W2912306803 hasConcept C10162356 @default.
- W2912306803 hasConcept C126322002 @default.
- W2912306803 hasConcept C134018914 @default.
- W2912306803 hasConcept C170493617 @default.
- W2912306803 hasConcept C180899940 @default.
- W2912306803 hasConcept C181199279 @default.
- W2912306803 hasConcept C203014093 @default.
- W2912306803 hasConcept C2776352991 @default.
- W2912306803 hasConcept C2776914184 @default.
- W2912306803 hasConcept C2777361909 @default.
- W2912306803 hasConcept C2778078955 @default.
- W2912306803 hasConcept C2778329239 @default.