FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912307432> ?p ?o ?g. }

• W2912307432 abstract "Background and Aim: Sleep deprivation (SD) causes deficit of cognition, but the mechanisms remain to be fully established. Hydrogen sulfide (H2S) plays an important role in the formation of cognition, while excessive and prolonged autophagy in hippocampus triggers cognitive disorder. In this work, we proposed that disturbances in hippocampal endogenous H2S generation and autophagy might be involved in SD-induced cognitive impairment. Methods: After treatment of adult male wistar rats with 72-h SD, the Y-maze test, object location test (OLT), novel object recognition test (NORT) and the Morris water maze (MWM) test were performed to determine the cognitive function. The autophagosome formation was observed with electron microscope. Generation of endogenous H2S in the hippocampus of rats was detected using unisense H2S microsensor method. The expressions of cystathionine-βsynthase (CBS), 3-mercaptopyruvate sulfurtransferase (3-MST), beclin-1, light chain LC3 II/LC3 I, and p62 in the hippocampus were assessed by western blotting. Results: The Y-maze, OLT, NORT and MWM test demonstrated that SD-exposed rats exhibited cognitive dysfunction. SD triggered the elevation of hippocampal autophagy as evidenced by enhancement of autophagosome, up-regulations of beclin-1 and LC3 II/LC3 I, and down-regulation of p62. Meanwhile, the generation of endogenous H2S and the expressions of CBS and 3-MST (H2S producing enzyme) in the hippocampus of SD-treated rats were reduced. Conclusion: These results suggested that inhibition of endogenous H2S generation and excessiveness of autophagy in hippocampus are involved in SD-induced cognitive impairment." @default.
• W2912307432 created "2019-02-21" @default.
• W2912307432 creator A5001836482 @default.
• W2912307432 creator A5002233203 @default.
• W2912307432 creator A5002711155 @default.
• W2912307432 creator A5016723064 @default.
• W2912307432 creator A5044321008 @default.
• W2912307432 creator A5056345834 @default.
• W2912307432 creator A5064189236 @default.
• W2912307432 creator A5079922960 @default.
• W2912307432 creator A5083507260 @default.
• W2912307432 creator A5088695928 @default.
• W2912307432 date "2019-01-24" @default.
• W2912307432 modified "2023-10-17" @default.
• W2912307432 title "Inhibited Endogenous H2S Generation and Excessive Autophagy in Hippocampus Contribute to Sleep Deprivation-Induced Cognitive Impairment" @default.
• W2912307432 cites W1064041282 @default.
• W2912307432 cites W11892526 @default.
• W2912307432 cites W1515552610 @default.
• W2912307432 cites W1539823279 @default.
• W2912307432 cites W1968745677 @default.
• W2912307432 cites W1970819735 @default.
• W2912307432 cites W1971154550 @default.
• W2912307432 cites W1985124617 @default.
• W2912307432 cites W1995826869 @default.
• W2912307432 cites W2005980540 @default.
• W2912307432 cites W2015789613 @default.
• W2912307432 cites W2021141949 @default.
• W2912307432 cites W2030430356 @default.
• W2912307432 cites W2052012904 @default.
• W2912307432 cites W2067091953 @default.
• W2912307432 cites W2069110711 @default.
• W2912307432 cites W2069678434 @default.
• W2912307432 cites W2071919400 @default.
• W2912307432 cites W2079613741 @default.
• W2912307432 cites W2085957688 @default.
• W2912307432 cites W2086155425 @default.
• W2912307432 cites W2091232863 @default.
• W2912307432 cites W2091482008 @default.
• W2912307432 cites W2093581304 @default.
• W2912307432 cites W2103880422 @default.
• W2912307432 cites W2107471829 @default.
• W2912307432 cites W2113365874 @default.
• W2912307432 cites W2125461230 @default.
• W2912307432 cites W2163225965 @default.
• W2912307432 cites W2165375176 @default.
• W2912307432 cites W2174054701 @default.
• W2912307432 cites W2192391472 @default.
• W2912307432 cites W2208220125 @default.
• W2912307432 cites W2213408176 @default.
• W2912307432 cites W2345907209 @default.
• W2912307432 cites W2409415139 @default.
• W2912307432 cites W2416843139 @default.
• W2912307432 cites W2464503524 @default.
• W2912307432 cites W2466930932 @default.
• W2912307432 cites W2522700401 @default.
• W2912307432 cites W2530993234 @default.
• W2912307432 cites W2562452400 @default.
• W2912307432 cites W2566199035 @default.
• W2912307432 cites W2566687904 @default.
• W2912307432 cites W2573732020 @default.
• W2912307432 cites W2590185032 @default.
• W2912307432 cites W2594371116 @default.
• W2912307432 cites W2594886380 @default.
• W2912307432 cites W2600000174 @default.
• W2912307432 cites W2604586858 @default.
• W2912307432 cites W2606294671 @default.
• W2912307432 cites W2612991505 @default.
• W2912307432 cites W2737904430 @default.
• W2912307432 cites W2740732011 @default.
• W2912307432 cites W2746531389 @default.
• W2912307432 cites W2778158425 @default.
• W2912307432 cites W2781773803 @default.
• W2912307432 cites W2781793537 @default.
• W2912307432 cites W2784465425 @default.
• W2912307432 cites W2789428095 @default.
• W2912307432 cites W2790286704 @default.
• W2912307432 cites W2790773229 @default.
• W2912307432 cites W2792279401 @default.
• W2912307432 cites W2800106432 @default.
• W2912307432 cites W2800916535 @default.
• W2912307432 cites W2803449879 @default.
• W2912307432 cites W2803820885 @default.
• W2912307432 cites W73430731 @default.
• W2912307432 cites W874697581 @default.
• W2912307432 doi "https://doi.org/10.3389/fpsyg.2019.00053" @default.
• W2912307432 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6353847" @default.
• W2912307432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30733697" @default.
• W2912307432 hasPublicationYear "2019" @default.
• W2912307432 type Work @default.
• W2912307432 sameAs 2912307432 @default.
• W2912307432 citedByCount "22" @default.
• W2912307432 countsByYear W29123074322020 @default.
• W2912307432 countsByYear W29123074322021 @default.
• W2912307432 countsByYear W29123074322022 @default.
• W2912307432 countsByYear W29123074322023 @default.
• W2912307432 crossrefType "journal-article" @default.
• W2912307432 hasAuthorship W2912307432A5001836482 @default.
• W2912307432 hasAuthorship W2912307432A5002233203 @default.
• W2912307432 hasAuthorship W2912307432A5002711155 @default.
• W2912307432 hasAuthorship W2912307432A5016723064 @default.

• next