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- W2912309272 abstract "Glucose metabolism in vertebrate retinas is dominated by aerobic glycolysis (the Warburg Effect), which allows only a small fraction of glucose-derived pyruvate to enter mitochondria. Here, we report evidence that the small fraction of pyruvate in photoreceptors that does get oxidized by their mitochondria is required for visual function, photoreceptor structure and viability, normal neuron-glial interaction, and homeostasis of retinal metabolism. The mitochondrial pyruvate carrier (MPC) links glycolysis and mitochondrial metabolism. Retina-specific deletion of MPC1 results in progressive retinal degeneration and decline of visual function in both rod and cone photoreceptors. Using targeted-metabolomics and 13C tracers, we found that MPC1 is required for cytosolic reducing power maintenance, glutamine/glutamate metabolism, and flexibility in fuel utilization." @default.
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- W2912309272 date "2019-02-11" @default.
- W2912309272 modified "2023-10-16" @default.
- W2912309272 title "Loss of MPC1 reprograms retinal metabolism to impair visual function" @default.
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- W2912309272 doi "https://doi.org/10.1073/pnas.1812941116" @default.
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