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- W2912309767 abstract "Trametes robiniophila Murr also known as Huaier, one of the traditional Chinese medicines, has been shown an effective adjuvant of cancer therapy. Accumulating evidence suggests that the anti-cancer effects of Huaier can be briefly divided into two aspects: the direct effects on tumor cells and the indirect effects on immune cells. In vitro and in vivo experiment showed Huaier directly inhibited tumor cell proliferation, induced tumor cell death, prevented metastasis and interfered with angiogenesis via various signaling pathways. The immunomodulatory effect of Huaier is associated with enhancement of the number and function of CD4+ T cells and NK cells, regulation of the polarization and function of macrophages, and elevated secretion of immune stimulatory cytokines. In this review, the anti-cancer effects and combined treatments of Huaier with other anti-cancer therapies, and the underlying mechanisms are summarized and discussed." @default.
- W2912309767 created "2019-02-21" @default.
- W2912309767 creator A5007959136 @default.
- W2912309767 creator A5061652893 @default.
- W2912309767 creator A5081879402 @default.
- W2912309767 creator A5085596965 @default.
- W2912309767 date "2019-02-01" @default.
- W2912309767 modified "2023-09-28" @default.
- W2912309767 title "<p><em>Trametes robiniophila</em> Murr: a traditional Chinese medicine with potent anti-tumor effects</p>" @default.
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- W2912309767 doi "https://doi.org/10.2147/cmar.s193174" @default.
- W2912309767 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6389013" @default.
- W2912309767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30863164" @default.
- W2912309767 hasPublicationYear "2019" @default.
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