FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912309925> ?p ?o ?g. }

• W2912309925 endingPage "29" @default.
• W2912309925 startingPage "23" @default.
• W2912309925 abstract "L-Ornithine L-aspartate (LOLA), a stable salt of L-ornithine and L-aspartate, readily dissociates into its constituent amino acids that are readily absorbed by active transport, distributed, and metabolized. L-ornithine serves as an intermediary in the urea cycle in periportal hepatocytes in the liver and as an activator of carbamoyl phosphate synthetase, and, like L-aspartate, by transamination to glutamate via glutamine synthetase in perivenous hepatocytes as well as by skeletal muscle and brain. By way of these metabolic pathways, both amino acids participate in reactions whereby the ammonia molecule is incorporated into urea and glutamine and it is the nature, cellular, and biological location of these pathways that underpins the application of LOLA as an effective ammonia-lowering strategy widely used for the management and treatment of hepatic encephalopathy. These metabolic pathways were elucidated based upon studies in experimental animals and were confirmed by studies in patients with severe liver diseases. More recent studies suggest that LOLA may have additional direct hepatoprotective properties. Moreover, its use may result in improvements in skeletal muscle function in cirrhosis." @default.
• W2912309925 created "2019-02-21" @default.
• W2912309925 creator A5080645554 @default.
• W2912309925 creator A5091782144 @default.
• W2912309925 date "2019-01-31" @default.
• W2912309925 modified "2023-10-12" @default.
• W2912309925 title "Pharmacokinetic and Pharmacodynamic Properties of l-Ornithine l-Aspartate (LOLA) in Hepatic Encephalopathy" @default.
• W2912309925 cites W125689505 @default.
• W2912309925 cites W1809464205 @default.
• W2912309925 cites W1825874823 @default.
• W2912309925 cites W1913224606 @default.
• W2912309925 cites W1967216895 @default.
• W2912309925 cites W1970278510 @default.
• W2912309925 cites W1979385954 @default.
• W2912309925 cites W2009520102 @default.
• W2912309925 cites W2019144300 @default.
• W2912309925 cites W2027951690 @default.
• W2912309925 cites W2031147070 @default.
• W2912309925 cites W2052720481 @default.
• W2912309925 cites W2060374929 @default.
• W2912309925 cites W2073218335 @default.
• W2912309925 cites W2092623368 @default.
• W2912309925 cites W2094043570 @default.
• W2912309925 cites W2094732000 @default.
• W2912309925 cites W2112338657 @default.
• W2912309925 cites W2116594466 @default.
• W2912309925 cites W2117295873 @default.
• W2912309925 cites W2287727922 @default.
• W2912309925 cites W2399118907 @default.
• W2912309925 cites W240309487 @default.
• W2912309925 cites W2588938745 @default.
• W2912309925 cites W27282944 @default.
• W2912309925 cites W2804625278 @default.
• W2912309925 cites W50636397 @default.
• W2912309925 doi "https://doi.org/10.1007/s40265-018-1023-2" @default.
• W2912309925 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6416235" @default.
• W2912309925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30706424" @default.
• W2912309925 hasPublicationYear "2019" @default.
• W2912309925 type Work @default.
• W2912309925 sameAs 2912309925 @default.
• W2912309925 citedByCount "27" @default.
• W2912309925 countsByYear W29123099252019 @default.
• W2912309925 countsByYear W29123099252020 @default.
• W2912309925 countsByYear W29123099252021 @default.
• W2912309925 countsByYear W29123099252022 @default.
• W2912309925 countsByYear W29123099252023 @default.
• W2912309925 crossrefType "journal-article" @default.
• W2912309925 hasAuthorship W2912309925A5080645554 @default.
• W2912309925 hasAuthorship W2912309925A5091782144 @default.
• W2912309925 hasBestOaLocation W29123099251 @default.
• W2912309925 hasConcept C112705442 @default.
• W2912309925 hasConcept C126322002 @default.
• W2912309925 hasConcept C170493617 @default.
• W2912309925 hasConcept C185592680 @default.
• W2912309925 hasConcept C192989942 @default.
• W2912309925 hasConcept C2776796294 @default.
• W2912309925 hasConcept C2777214474 @default.
• W2912309925 hasConcept C2777468819 @default.
• W2912309925 hasConcept C2779289688 @default.
• W2912309925 hasConcept C2779349466 @default.
• W2912309925 hasConcept C2780325230 @default.
• W2912309925 hasConcept C2780365088 @default.
• W2912309925 hasConcept C2781099255 @default.
• W2912309925 hasConcept C515207424 @default.
• W2912309925 hasConcept C55493867 @default.
• W2912309925 hasConcept C61174792 @default.
• W2912309925 hasConcept C62231903 @default.
• W2912309925 hasConcept C68793091 @default.
• W2912309925 hasConcept C71924100 @default.
• W2912309925 hasConcept C77061444 @default.
• W2912309925 hasConcept C98274493 @default.
• W2912309925 hasConceptScore W2912309925C112705442 @default.
• W2912309925 hasConceptScore W2912309925C126322002 @default.
• W2912309925 hasConceptScore W2912309925C170493617 @default.
• W2912309925 hasConceptScore W2912309925C185592680 @default.
• W2912309925 hasConceptScore W2912309925C192989942 @default.
• W2912309925 hasConceptScore W2912309925C2776796294 @default.
• W2912309925 hasConceptScore W2912309925C2777214474 @default.
• W2912309925 hasConceptScore W2912309925C2777468819 @default.
• W2912309925 hasConceptScore W2912309925C2779289688 @default.
• W2912309925 hasConceptScore W2912309925C2779349466 @default.
• W2912309925 hasConceptScore W2912309925C2780325230 @default.
• W2912309925 hasConceptScore W2912309925C2780365088 @default.
• W2912309925 hasConceptScore W2912309925C2781099255 @default.
• W2912309925 hasConceptScore W2912309925C515207424 @default.
• W2912309925 hasConceptScore W2912309925C55493867 @default.
• W2912309925 hasConceptScore W2912309925C61174792 @default.
• W2912309925 hasConceptScore W2912309925C62231903 @default.
• W2912309925 hasConceptScore W2912309925C68793091 @default.
• W2912309925 hasConceptScore W2912309925C71924100 @default.
• W2912309925 hasConceptScore W2912309925C77061444 @default.
• W2912309925 hasConceptScore W2912309925C98274493 @default.
• W2912309925 hasIssue "S1" @default.
• W2912309925 hasLocation W29123099251 @default.
• W2912309925 hasLocation W29123099252 @default.
• W2912309925 hasLocation W29123099253 @default.
• W2912309925 hasLocation W29123099254 @default.
• W2912309925 hasOpenAccess W2912309925 @default.

• next