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- W2912321797 abstract "Mitochondria are important organelles for cellular physiology considering their role in generation of ATP and reactive oxygen species, calcium homeostasis and programmed cell death. In particular, mitochondria produce ATP via oxidative phosphorylation. Mitochondrial activity must be tightly regulated as alteration to the organelle functions can lead to different pathologies including neurodegenerative and metabolic diseases. Phosphorylation of mitochondrial proteins, including the enzymes involved in oxidative phosphorylation, emerged as an important way to modulate mitochondrial metabolism according to physiological conditions. In recent years, several kinases and phosphatases were observed within mitochondria. Numerous phosphorylation sites among the components of the oxidative phosphorylation machinery were observed. These findings open a new field in mitochondrial physiology and cellular biology, showing that well-known signalling pathways can reach proteins within mitochondria to adjust the organelle activity to extramitochondrial stimuli. Key Concepts Mitochondria provide the most part of ATP used by cells via oxidative phosphorylation. Kinases and phosphatases are present within mitochondria. Intramitochondrial kinases target several components of the oxidative phosphorylation machinery. Phosphorylation of mitochondrial proteins represents an important mean to modulate oxidative phosphorylation and other mitochondrial functions. Better knowledge about translocation of kinases and phosphatases inside mitochondria is needed." @default.
- W2912321797 created "2019-02-21" @default.
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- W2912321797 date "2017-10-28" @default.
- W2912321797 modified "2023-10-18" @default.
- W2912321797 title "Role of Protein Phosphorylation among Oxidative Phosphorylation Components" @default.
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- W2912321797 doi "https://doi.org/10.1002/9780470015902.a0027586" @default.
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