FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912321830> ?p ?o ?g. }

• W2912321830 endingPage "80" @default.
• W2912321830 startingPage "67" @default.
• W2912321830 abstract "DNA methylation status is closely associated with diverse diseases, and is generally more stable than gene expression, thus abnormal DNA methylation could be important biomarkers for tumor diagnosis, treatment and prognosis. However, the signatures regarding DNA methylation changes for pan-cancer diagnosis and prognosis are less explored. Here we systematically analyzed the genome-wide DNA methylation patterns in diverse TCGA cancers with machine learning. We identified seven CpG sites that could effectively discriminate tumor samples from adjacent normal tissue samples for 12 main cancers of TCGA (1216 samples, AUC > 0.99). Those seven potential diagnostic biomarkers were further validated in the other 9 different TCGA cancers and 4 independent datasets (AUC > 0.92). Three out of the seven CpG sites were correlated with cell division, DNA replication and cell cycle. We also identified 12 CpG sites that can effectively distinguish 26 different cancers (7605 samples), and the result was repeatable in independent datasets as well as two disparate tumors with metastases (micro-average AUC > 0.89). Furthermore, a series of potential signatures that could significantly predict the prognosis of tumor patients for 7 different cancer were identified via survival analysis (p-value < 1e-4). Collectively, DNA methylation patterns vary greatly between tumor and adjacent normal tissues, as well as among different types of cancers. Our identified signatures may aid the decision of clinical diagnosis and prognosis for pan-cancer and the potential cancer-specific biomarkers could be used to predict the primary site of metastatic breast and prostate cancers." @default.
• W2912321830 created "2019-02-21" @default.
• W2912321830 creator A5048591018 @default.
• W2912321830 creator A5051377484 @default.
• W2912321830 creator A5089429812 @default.
• W2912321830 date "2019-01-02" @default.
• W2912321830 modified "2023-10-14" @default.
• W2912321830 title "Integrative analysis identifies potential DNA methylation biomarkers for pan-cancer diagnosis and prognosis" @default.
• W2912321830 cites W1493809946 @default.
• W2912321830 cites W1678356000 @default.
• W2912321830 cites W1781764024 @default.
• W2912321830 cites W1967220865 @default.
• W2912321830 cites W1976360212 @default.
• W2912321830 cites W1986241711 @default.
• W2912321830 cites W1998220759 @default.
• W2912321830 cites W2013045624 @default.
• W2912321830 cites W2034879676 @default.
• W2912321830 cites W2037966798 @default.
• W2912321830 cites W2041440766 @default.
• W2912321830 cites W2053856108 @default.
• W2912321830 cites W2068166663 @default.
• W2912321830 cites W2068523052 @default.
• W2912321830 cites W2069377300 @default.
• W2912321830 cites W2074448914 @default.
• W2912321830 cites W2090200262 @default.
• W2912321830 cites W2104760300 @default.
• W2912321830 cites W2111104102 @default.
• W2912321830 cites W2113524127 @default.
• W2912321830 cites W2125939156 @default.
• W2912321830 cites W2127431419 @default.
• W2912321830 cites W2132214277 @default.
• W2912321830 cites W2133465414 @default.
• W2912321830 cites W2147847895 @default.
• W2912321830 cites W2148521032 @default.
• W2912321830 cites W2158217645 @default.
• W2912321830 cites W2162178715 @default.
• W2912321830 cites W2272086068 @default.
• W2912321830 cites W2313222841 @default.
• W2912321830 cites W2341474791 @default.
• W2912321830 cites W2347980327 @default.
• W2912321830 cites W2430411139 @default.
• W2912321830 cites W2443032253 @default.
• W2912321830 cites W2487261336 @default.
• W2912321830 cites W2540263083 @default.
• W2912321830 cites W2559261911 @default.
• W2912321830 cites W2568536314 @default.
• W2912321830 cites W2578447104 @default.
• W2912321830 cites W2588731756 @default.
• W2912321830 cites W2588793968 @default.
• W2912321830 cites W2589143524 @default.
• W2912321830 cites W2598108680 @default.
• W2912321830 cites W2605688857 @default.
• W2912321830 cites W2625816300 @default.
• W2912321830 cites W2663574681 @default.
• W2912321830 cites W2766526974 @default.
• W2912321830 cites W2949685204 @default.
• W2912321830 doi "https://doi.org/10.1080/15592294.2019.1568178" @default.
• W2912321830 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6380428" @default.
• W2912321830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30696380" @default.
• W2912321830 hasPublicationYear "2019" @default.
• W2912321830 type Work @default.
• W2912321830 sameAs 2912321830 @default.
• W2912321830 citedByCount "80" @default.
• W2912321830 countsByYear W29123218302019 @default.
• W2912321830 countsByYear W29123218302020 @default.
• W2912321830 countsByYear W29123218302021 @default.
• W2912321830 countsByYear W29123218302022 @default.
• W2912321830 countsByYear W29123218302023 @default.
• W2912321830 crossrefType "journal-article" @default.
• W2912321830 hasAuthorship W2912321830A5048591018 @default.
• W2912321830 hasAuthorship W2912321830A5051377484 @default.
• W2912321830 hasAuthorship W2912321830A5089429812 @default.
• W2912321830 hasBestOaLocation W29123218301 @default.
• W2912321830 hasConcept C104317684 @default.
• W2912321830 hasConcept C121608353 @default.
• W2912321830 hasConcept C126322002 @default.
• W2912321830 hasConcept C140173407 @default.
• W2912321830 hasConcept C143998085 @default.
• W2912321830 hasConcept C150194340 @default.
• W2912321830 hasConcept C190727270 @default.
• W2912321830 hasConcept C2780192828 @default.
• W2912321830 hasConcept C2781197716 @default.
• W2912321830 hasConcept C33288867 @default.
• W2912321830 hasConcept C502942594 @default.
• W2912321830 hasConcept C54355233 @default.
• W2912321830 hasConcept C552990157 @default.
• W2912321830 hasConcept C71924100 @default.
• W2912321830 hasConcept C86803240 @default.
• W2912321830 hasConceptScore W2912321830C104317684 @default.
• W2912321830 hasConceptScore W2912321830C121608353 @default.
• W2912321830 hasConceptScore W2912321830C126322002 @default.
• W2912321830 hasConceptScore W2912321830C140173407 @default.
• W2912321830 hasConceptScore W2912321830C143998085 @default.
• W2912321830 hasConceptScore W2912321830C150194340 @default.
• W2912321830 hasConceptScore W2912321830C190727270 @default.
• W2912321830 hasConceptScore W2912321830C2780192828 @default.
• W2912321830 hasConceptScore W2912321830C2781197716 @default.
• W2912321830 hasConceptScore W2912321830C33288867 @default.

• next