FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912331978> ?p ?o ?g. }

• W2912331978 endingPage "49" @default.
• W2912331978 startingPage "36" @default.
• W2912331978 abstract "Prosthetic joint infection (PJI) is a well-known and persisting problem. Active release coatings have promise to provide early protection to an implant by eradicating small colony biofilm contaminants or planktonic bacteria that can form biofilm. Traditional antibiotics can be limited as active release agents in that they have limited effect against biofilms and develop resistance at sub-lethal concentrations. A unique first-in-class compound (CZ-01127) was assessed as the active release agent in a silicone (Si)-based coating to prevent PJI in a sheep model of joint space infection. Titanium (Ti) plugs contained a porous coated Ti (PCTi) region and polymer-coated region. Plugs were implanted into a femoral condyle of sheep to assess the effect of the Si polymer on cancellous bone ingrowth, the effect of CZ-01127 on bone ingrowth, and the ability of CZ-01127 to prevent PJI. Microbiological results showed that CZ-01127 was able to eradicate bacteria in the local region of the implanted plugs. Data further showed that Si did not adversely affect bone ingrowth. However, bacteria that reached the joint space (synovium) were not fully eradicated. Outcomes suggested that the CZ-01127 coating provided local protection to the implant system in a challenging model, the design of which could be beneficial for testing future antimicrobial therapies for PJI. Periprosthetic joint infection (PJI) is now commonplace, and constitutes an underlying problem that patients and physicians face. Active release antibiotic coatings have potential to prevent these infections. Traditional antibiotics are limited in their ability to eradicate bacteria that reside in biofilms, and are more susceptible to resistance development. This study addressed these limitations by testing the efficacy of a unique antimicrobial compound in a coating that was tested in a challenging sheep model of PJI. The unique coating was able to eradicate bacteria and prevent infection in the environment adjacent to the implant. Bacteria that escaped into the joint space still caused infection, yet benchmark data can be used to optimize the coating and translate it toward clinical use." @default.
• W2912331978 created "2019-02-21" @default.
• W2912331978 creator A5007845601 @default.
• W2912331978 creator A5009736822 @default.
• W2912331978 creator A5010532057 @default.
• W2912331978 creator A5035046073 @default.
• W2912331978 creator A5039865565 @default.
• W2912331978 creator A5055936811 @default.
• W2912331978 creator A5058946352 @default.
• W2912331978 creator A5059429975 @default.
• W2912331978 creator A5076002630 @default.
• W2912331978 creator A5082222509 @default.
• W2912331978 date "2019-07-01" @default.
• W2912331978 modified "2023-10-16" @default.
• W2912331978 title "In vivo analysis of a first-in-class tri-alkyl norspermidine-biaryl antibiotic in an active release coating to reduce the risk of implant-related infection" @default.
• W2912331978 cites W1513339934 @default.
• W2912331978 cites W1544710209 @default.
• W2912331978 cites W1947538072 @default.
• W2912331978 cites W1969593481 @default.
• W2912331978 cites W1977002312 @default.
• W2912331978 cites W1979103710 @default.
• W2912331978 cites W1983255179 @default.
• W2912331978 cites W1986707538 @default.
• W2912331978 cites W1987740284 @default.
• W2912331978 cites W1987883392 @default.
• W2912331978 cites W1997749425 @default.
• W2912331978 cites W2005965041 @default.
• W2912331978 cites W2006240870 @default.
• W2912331978 cites W2019681486 @default.
• W2912331978 cites W2024764217 @default.
• W2912331978 cites W2030867698 @default.
• W2912331978 cites W2032992088 @default.
• W2912331978 cites W2037200497 @default.
• W2912331978 cites W2043094235 @default.
• W2912331978 cites W2051547677 @default.
• W2912331978 cites W2054759379 @default.
• W2912331978 cites W2059274603 @default.
• W2912331978 cites W2068370094 @default.
• W2912331978 cites W2074593525 @default.
• W2912331978 cites W2075359954 @default.
• W2912331978 cites W2076700295 @default.
• W2912331978 cites W2087031595 @default.
• W2912331978 cites W2089560383 @default.
• W2912331978 cites W2102568114 @default.
• W2912331978 cites W2103365030 @default.
• W2912331978 cites W2103743650 @default.
• W2912331978 cites W2108152814 @default.
• W2912331978 cites W2113751614 @default.
• W2912331978 cites W2122420555 @default.
• W2912331978 cites W2131727615 @default.
• W2912331978 cites W2150525723 @default.
• W2912331978 cites W2154933453 @default.
• W2912331978 cites W2170863086 @default.
• W2912331978 cites W2171782979 @default.
• W2912331978 cites W2320299291 @default.
• W2912331978 cites W2398405343 @default.
• W2912331978 cites W2469419934 @default.
• W2912331978 cites W2737588732 @default.
• W2912331978 cites W2761875146 @default.
• W2912331978 cites W2791630744 @default.
• W2912331978 cites W4254657230 @default.
• W2912331978 doi "https://doi.org/10.1016/j.actbio.2019.01.055" @default.
• W2912331978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30710710" @default.
• W2912331978 hasPublicationYear "2019" @default.
• W2912331978 type Work @default.
• W2912331978 sameAs 2912331978 @default.
• W2912331978 citedByCount "21" @default.
• W2912331978 countsByYear W29123319782019 @default.
• W2912331978 countsByYear W29123319782020 @default.
• W2912331978 countsByYear W29123319782021 @default.
• W2912331978 countsByYear W29123319782022 @default.
• W2912331978 countsByYear W29123319782023 @default.
• W2912331978 crossrefType "journal-article" @default.
• W2912331978 hasAuthorship W2912331978A5007845601 @default.
• W2912331978 hasAuthorship W2912331978A5009736822 @default.
• W2912331978 hasAuthorship W2912331978A5010532057 @default.
• W2912331978 hasAuthorship W2912331978A5035046073 @default.
• W2912331978 hasAuthorship W2912331978A5039865565 @default.
• W2912331978 hasAuthorship W2912331978A5055936811 @default.
• W2912331978 hasAuthorship W2912331978A5058946352 @default.
• W2912331978 hasAuthorship W2912331978A5059429975 @default.
• W2912331978 hasAuthorship W2912331978A5076002630 @default.
• W2912331978 hasAuthorship W2912331978A5082222509 @default.
• W2912331978 hasConcept C136229726 @default.
• W2912331978 hasConcept C141071460 @default.
• W2912331978 hasConcept C150903083 @default.
• W2912331978 hasConcept C159985019 @default.
• W2912331978 hasConcept C192562407 @default.
• W2912331978 hasConcept C207001950 @default.
• W2912331978 hasConcept C2778120723 @default.
• W2912331978 hasConcept C2778336525 @default.
• W2912331978 hasConcept C2781411149 @default.
• W2912331978 hasConcept C2781448156 @default.
• W2912331978 hasConcept C4937899 @default.
• W2912331978 hasConcept C501593827 @default.
• W2912331978 hasConcept C523546767 @default.
• W2912331978 hasConcept C54355233 @default.
• W2912331978 hasConcept C58123911 @default.

• next