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- W2912332247 abstract "Mitochondrial Ca2+ transient is the earliest discovered organellar Ca2+ signaling pathway. It consist of a Ca2+ influx, mediated by mitochondrial Ca2+ uniporter (MCU), and mitochondrial Ca2+ efflux mediated by a Na+/Ca2+ exchanger (NCLX). Mitochondrial Ca2+ signaling machinery plays a fundamental role in linking metabolic activity to cellular Ca2+ signaling, and in controlling local Ca2+ concertation in distinct cellular compartments. Impaired balance between mitochondrial Ca2+ influx and efflux leads to mitochondrial Ca2+ overload, an early and key event in ischemic or neurodegenerative syndromes. Molecular identification of NCLX and MCU happened only recently. Surprisingly, MCU knockout yielded a relatively mild phenotype while conditional knockout of NCLX led to a rapid fatal heart failure. Here we will focus on recent functional and molecular studies on NCLX structure and its mode of regulation. We will describe the unique crosstalk of this exchanger with Na+ and Ca2+ signaling pathways in the cell membrane and the endoplasmic reticulum, and with protein kinases that posttranslationally modulate NCLX activity. We will critically compare selectivity of pharmacological blockers versus molecular control of NCLX expression and activity. Finally we will discuss why this exchanger is essential for survival and can serve as an attractive therapeutic target." @default.
- W2912332247 created "2019-02-21" @default.
- W2912332247 creator A5072422287 @default.
- W2912332247 creator A5074048649 @default.
- W2912332247 date "2019-10-01" @default.
- W2912332247 modified "2023-09-29" @default.
- W2912332247 title "Functional properties and mode of regulation of the mitochondrial Na+/Ca2+ exchanger, NCLX" @default.
- W2912332247 cites W1248810041 @default.
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- W2912332247 cites W1523821352 @default.
- W2912332247 cites W1556946959 @default.
- W2912332247 cites W1588570886 @default.
- W2912332247 cites W1616183675 @default.
- W2912332247 cites W1622243645 @default.
- W2912332247 cites W1712887138 @default.
- W2912332247 cites W1800295875 @default.
- W2912332247 cites W1853409833 @default.
- W2912332247 cites W1963791094 @default.
- W2912332247 cites W1968257316 @default.
- W2912332247 cites W1969709153 @default.
- W2912332247 cites W1972718661 @default.
- W2912332247 cites W1974941330 @default.
- W2912332247 cites W1977230497 @default.
- W2912332247 cites W1985677046 @default.
- W2912332247 cites W1986213783 @default.
- W2912332247 cites W1991078304 @default.
- W2912332247 cites W1992868369 @default.
- W2912332247 cites W2000535878 @default.
- W2912332247 cites W2005641666 @default.
- W2912332247 cites W2007202933 @default.
- W2912332247 cites W2008657621 @default.
- W2912332247 cites W2010932100 @default.
- W2912332247 cites W2026644067 @default.
- W2912332247 cites W2029596015 @default.
- W2912332247 cites W2032547267 @default.
- W2912332247 cites W2032781637 @default.
- W2912332247 cites W2038071287 @default.
- W2912332247 cites W2041874682 @default.
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- W2912332247 cites W2070869619 @default.
- W2912332247 cites W2074800090 @default.
- W2912332247 cites W2085111073 @default.
- W2912332247 cites W2088629175 @default.
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- W2912332247 cites W2115322996 @default.
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- W2912332247 cites W2165811472 @default.
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- W2912332247 cites W2294971561 @default.
- W2912332247 cites W2405114694 @default.
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- W2912332247 doi "https://doi.org/10.1016/j.semcdb.2019.01.009" @default.
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