FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912336187> ?p ?o ?g. }

• W2912336187 endingPage "337" @default.
• W2912336187 startingPage "326" @default.
• W2912336187 abstract "Stroke is one of the major leading causes of death and disability worldwide, and post-stroke cognitive impairment is a major contributor to this disability. Astragaloside IV (AST-IV) is a primary bioactive compound of Radix Astragali, which is widely used in traditional Chinese medicine to treat stroke. AST-IV was found to possess cognition-enhancing properties against ischemic stroke; however, the mechanisms underlying this effect remain largely elusive. Mitochondrial health is critical to cell viability after ischemic injury. Cyclic AMP response element-binding protein (CREB) is a transcription factor that can be activated by protein kinase A (PKA) to preserve mitochondria, regulate memory and cognitive functions. We used an in vitro model of ischemic injury via oxygen and glucose deprivation (OGD) of cultured neurons, which led to PKA inactivation and decreased CREB phosphorylation, reduced cell viability, and increased neuronal apoptosis. We hypothesized that AST-IV could protect OGD-exposed cerebral cortical neurons by modulating the PKA/CREB signaling pathway and preserving mitochondrial function. We found that the mitochondrial and cellular injuries induced by OGD were reversed following treatment with AST-IV. The activity of neuronal mitochondria was evaluated by measuring the mitochondrial potential and the levels of reactive oxygen species (ROS) and adenosine triphosphate (ATP). AST-IV significantly enhanced PKA and CREB phosphorylation and prevented OGD-induced mitochondrial dysfunction, thereby protecting neurons exposed to OGD from injury and death. Furthermore, the effects of AST-IV were partially blocked by a PKA inhibitor. Collectively, these data elucidated the molecular mechanisms underlying the protective effects of AST-IV against ischemic injury in cortical neurons." @default.
• W2912336187 created "2019-02-21" @default.
• W2912336187 creator A5004280162 @default.
• W2912336187 creator A5013770557 @default.
• W2912336187 creator A5036612380 @default.
• W2912336187 creator A5055621456 @default.
• W2912336187 creator A5064411870 @default.
• W2912336187 creator A5071178564 @default.
• W2912336187 date "2019-04-01" @default.
• W2912336187 modified "2023-09-27" @default.
• W2912336187 title "Astragaloside IV Protects Primary Cerebral Cortical Neurons from Oxygen and Glucose Deprivation/Reoxygenation by Activating the PKA/CREB Pathway" @default.
• W2912336187 cites W11920071 @default.
• W2912336187 cites W1523213544 @default.
• W2912336187 cites W1589179621 @default.
• W2912336187 cites W1688330163 @default.
• W2912336187 cites W1964912041 @default.
• W2912336187 cites W1979007089 @default.
• W2912336187 cites W1981261198 @default.
• W2912336187 cites W1982854390 @default.
• W2912336187 cites W1982948052 @default.
• W2912336187 cites W1998127571 @default.
• W2912336187 cites W1998454166 @default.
• W2912336187 cites W1999357790 @default.
• W2912336187 cites W2009784224 @default.
• W2912336187 cites W2011801844 @default.
• W2912336187 cites W2013120577 @default.
• W2912336187 cites W2014961329 @default.
• W2912336187 cites W2016667860 @default.
• W2912336187 cites W2022219828 @default.
• W2912336187 cites W2022324453 @default.
• W2912336187 cites W2025211038 @default.
• W2912336187 cites W2027456070 @default.
• W2912336187 cites W2037864697 @default.
• W2912336187 cites W2066349217 @default.
• W2912336187 cites W2076598575 @default.
• W2912336187 cites W2081339485 @default.
• W2912336187 cites W2090122461 @default.
• W2912336187 cites W2092146469 @default.
• W2912336187 cites W2092588620 @default.
• W2912336187 cites W2124117141 @default.
• W2912336187 cites W2135642570 @default.
• W2912336187 cites W2135943549 @default.
• W2912336187 cites W2142192946 @default.
• W2912336187 cites W2151495088 @default.
• W2912336187 cites W2157965986 @default.
• W2912336187 cites W2158962985 @default.
• W2912336187 cites W2163245212 @default.
• W2912336187 cites W2163919948 @default.
• W2912336187 cites W2165201727 @default.
• W2912336187 cites W2167091449 @default.
• W2912336187 cites W2187090880 @default.
• W2912336187 cites W2294074260 @default.
• W2912336187 cites W2344634324 @default.
• W2912336187 cites W2349572554 @default.
• W2912336187 cites W2469512964 @default.
• W2912336187 cites W2494249514 @default.
• W2912336187 cites W2512318295 @default.
• W2912336187 cites W2520186370 @default.
• W2912336187 cites W2550313708 @default.
• W2912336187 cites W2563704870 @default.
• W2912336187 cites W2576382126 @default.
• W2912336187 cites W2588884896 @default.
• W2912336187 cites W2592059405 @default.
• W2912336187 cites W2765201051 @default.
• W2912336187 cites W2766366171 @default.
• W2912336187 cites W2766514860 @default.
• W2912336187 cites W2774435753 @default.
• W2912336187 cites W2780295374 @default.
• W2912336187 cites W2781084432 @default.
• W2912336187 cites W2792061750 @default.
• W2912336187 cites W2797458291 @default.
• W2912336187 cites W2889127185 @default.
• W2912336187 doi "https://doi.org/10.1016/j.neuroscience.2019.01.040" @default.
• W2912336187 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30708047" @default.
• W2912336187 hasPublicationYear "2019" @default.
• W2912336187 type Work @default.
• W2912336187 sameAs 2912336187 @default.
• W2912336187 citedByCount "33" @default.
• W2912336187 countsByYear W29123361872019 @default.
• W2912336187 countsByYear W29123361872020 @default.
• W2912336187 countsByYear W29123361872021 @default.
• W2912336187 countsByYear W29123361872022 @default.
• W2912336187 countsByYear W29123361872023 @default.
• W2912336187 crossrefType "journal-article" @default.
• W2912336187 hasAuthorship W2912336187A5004280162 @default.
• W2912336187 hasAuthorship W2912336187A5013770557 @default.
• W2912336187 hasAuthorship W2912336187A5036612380 @default.
• W2912336187 hasAuthorship W2912336187A5055621456 @default.
• W2912336187 hasAuthorship W2912336187A5064411870 @default.
• W2912336187 hasAuthorship W2912336187A5071178564 @default.
• W2912336187 hasBestOaLocation W29123361871 @default.
• W2912336187 hasConcept C104317684 @default.
• W2912336187 hasConcept C11960822 @default.
• W2912336187 hasConcept C126322002 @default.
• W2912336187 hasConcept C1629964 @default.
• W2912336187 hasConcept C185592680 @default.
• W2912336187 hasConcept C190283241 @default.
• W2912336187 hasConcept C25498285 @default.

• next