Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912342382> ?p ?o ?g. }
- W2912342382 abstract "Abstract Few studies implicate immunoregulatory gene expression in tumor cells in arbitrating brain tumor progression. Here we show that fibrinogen-like protein 2 (FGL2) is highly expressed in glioma stem cells and primary glioblastoma (GBM) cells. FGL2 knockout in tumor cells did not affect tumor-cell proliferation in vitro or tumor progression in immunodeficient mice but completely impaired GBM progression in immune-competent mice. This impairment was reversed in mice with a defect in dendritic cells (DCs) or CD103 + DC differentiation in the brain and in tumor-draining lymph nodes. The presence of FGL2 in tumor cells inhibited granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced CD103 + DC differentiation by suppressing NF-κB, STAT1/5, and p38 activation. These findings are relevant to GBM patients because a low level of FGL2 expression with concurrent high GM-CSF expression is associated with higher CD8B expression and longer survival. These data provide a rationale for therapeutic inhibition of FGL2 in brain tumors." @default.
- W2912342382 created "2019-02-21" @default.
- W2912342382 creator A5001498193 @default.
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- W2912342382 date "2019-01-25" @default.
- W2912342382 modified "2023-10-11" @default.
- W2912342382 title "FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation" @default.
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- W2912342382 doi "https://doi.org/10.1038/s41467-018-08271-x" @default.
- W2912342382 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6347641" @default.
- W2912342382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30683885" @default.
- W2912342382 hasPublicationYear "2019" @default.
- W2912342382 type Work @default.
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