Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912345512> ?p ?o ?g. }
- W2912345512 abstract "Abstract KAP1 (KRAB-domain associated protein 1) plays a fundamental role in regulating gene expression in mammalian cells by recruiting different transcription factors and altering the chromatin state. In doing so, KAP1 acts both as a platform for macromolecular interactions and as an E3 SUMO ligase. This work sheds light on the overall organization of the full-length protein combining solution scattering diffraction data, integrative modeling and single-molecule experiments. We show that KAP1 is an elongated antiparallel dimer with a native asymmetry at the C-terminal domain. This conformation supports our finding that the RING domain contributes to KAP1 auto-SUMOylation. Importantly, this intrinsic asymmetry has key functional implications for the KAP1 network of interactions, as the heterochromatin protein 1 (HP1) occupies only one of the two putative HP1 binding sites on the KAP1 dimer, resulting in an unexpected stoichiometry, even in the context of chromatin fibers." @default.
- W2912345512 created "2019-02-21" @default.
- W2912345512 creator A5009307435 @default.
- W2912345512 creator A5014052655 @default.
- W2912345512 creator A5024361562 @default.
- W2912345512 creator A5028393656 @default.
- W2912345512 creator A5038405174 @default.
- W2912345512 creator A5045614596 @default.
- W2912345512 creator A5046551506 @default.
- W2912345512 creator A5065373001 @default.
- W2912345512 creator A5065598178 @default.
- W2912345512 creator A5079565994 @default.
- W2912345512 creator A5082365845 @default.
- W2912345512 creator A5082705283 @default.
- W2912345512 date "2019-02-19" @default.
- W2912345512 modified "2023-10-01" @default.
- W2912345512 title "KAP1 is an antiparallel dimer with a natively functional asymmetry" @default.
- W2912345512 cites W138094741 @default.
- W2912345512 cites W1837454973 @default.
- W2912345512 cites W1841489266 @default.
- W2912345512 cites W1964333133 @default.
- W2912345512 cites W1975317507 @default.
- W2912345512 cites W1976122783 @default.
- W2912345512 cites W1976732528 @default.
- W2912345512 cites W1977038370 @default.
- W2912345512 cites W1979187818 @default.
- W2912345512 cites W1981010326 @default.
- W2912345512 cites W1982126789 @default.
- W2912345512 cites W1983394549 @default.
- W2912345512 cites W1986335988 @default.
- W2912345512 cites W1991357892 @default.
- W2912345512 cites W1996076891 @default.
- W2912345512 cites W1997807500 @default.
- W2912345512 cites W1998631287 @default.
- W2912345512 cites W1999141289 @default.
- W2912345512 cites W2002198253 @default.
- W2912345512 cites W2007835479 @default.
- W2912345512 cites W2010276959 @default.
- W2912345512 cites W2012562488 @default.
- W2912345512 cites W2014061560 @default.
- W2912345512 cites W2015735594 @default.
- W2912345512 cites W2016286719 @default.
- W2912345512 cites W2018134526 @default.
- W2912345512 cites W2019292967 @default.
- W2912345512 cites W2019542560 @default.
- W2912345512 cites W2027085235 @default.
- W2912345512 cites W2029667189 @default.
- W2912345512 cites W2031203839 @default.
- W2912345512 cites W2032499969 @default.
- W2912345512 cites W2038657349 @default.
- W2912345512 cites W2038841550 @default.
- W2912345512 cites W2039542760 @default.
- W2912345512 cites W2047214756 @default.
- W2912345512 cites W2049579790 @default.
- W2912345512 cites W2056734463 @default.
- W2912345512 cites W2059091401 @default.
- W2912345512 cites W2059200934 @default.
- W2912345512 cites W2063659835 @default.
- W2912345512 cites W2065283382 @default.
- W2912345512 cites W2070867144 @default.
- W2912345512 cites W2072654958 @default.
- W2912345512 cites W2072674961 @default.
- W2912345512 cites W2073285188 @default.
- W2912345512 cites W2075431236 @default.
- W2912345512 cites W2085630342 @default.
- W2912345512 cites W2087355433 @default.
- W2912345512 cites W2088335689 @default.
- W2912345512 cites W2088895400 @default.
- W2912345512 cites W2096787803 @default.
- W2912345512 cites W2098589211 @default.
- W2912345512 cites W2098646008 @default.
- W2912345512 cites W2098846501 @default.
- W2912345512 cites W2100197820 @default.
- W2912345512 cites W2101281806 @default.
- W2912345512 cites W2101659058 @default.
- W2912345512 cites W2104234755 @default.
- W2912345512 cites W2104571078 @default.
- W2912345512 cites W2105073128 @default.
- W2912345512 cites W2106109160 @default.
- W2912345512 cites W2110817748 @default.
- W2912345512 cites W2114900293 @default.
- W2912345512 cites W2115167726 @default.
- W2912345512 cites W2120782274 @default.
- W2912345512 cites W2122215608 @default.
- W2912345512 cites W2124036399 @default.
- W2912345512 cites W2129274682 @default.
- W2912345512 cites W2131037087 @default.
- W2912345512 cites W2132629607 @default.
- W2912345512 cites W2136558899 @default.
- W2912345512 cites W2137027550 @default.
- W2912345512 cites W2143784856 @default.
- W2912345512 cites W2149525061 @default.
- W2912345512 cites W2151026121 @default.
- W2912345512 cites W2152326948 @default.
- W2912345512 cites W2153857286 @default.
- W2912345512 cites W2157352980 @default.
- W2912345512 cites W2160256607 @default.
- W2912345512 cites W2167279371 @default.
- W2912345512 cites W2171888347 @default.
- W2912345512 cites W2197410971 @default.