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• W2912347299 abstract "Abstract Cells cooperate, compete, and are attacked in nature, driving the evolution of mechanisms for recognizing self versus non-self. Filamentous fungal cells cooperate to form an interconnected colony while competing with genetically dissimilar colonies... Cells rarely exist alone, which drives the evolution of diverse mechanisms for identifying and responding appropriately to the presence of other nearby cells. Filamentous fungi depend on somatic cell-to-cell communication and fusion for the development and maintenance of a multicellular, interconnected colony that is characteristic of this group of organisms. The filamentous fungus Neurospora crassa is a model for investigating the mechanisms of somatic cell-to-cell communication and fusion. N. crassa cells chemotropically grow toward genetically similar cells, which ultimately make physical contact and undergo cell fusion. Here, we describe the development of a Pprm1-luciferase reporter system that differentiates whether genes function upstream or downstream of a conserved MAP kinase (MAPK) signaling complex, by using a set of mutants required for communication and cell fusion. The vast majority of these mutants are deficient for self-fusion and for fusion when paired with wild-type cells. However, the Δham-11 mutant is unique in that it fails to undergo self-fusion, but chemotropic interactions and cell fusion are restored in Δham-11 + wild-type interactions. In genetically dissimilar cells, chemotropic interactions are regulated by genetic differences at doc-1 and doc-2, which regulate prefusion non-self recognition; cells with dissimilar doc-1 and doc-2 alleles show greatly reduced cell-fusion frequencies. Here, we show that HAM-11 functions in parallel with the DOC-1 and DOC-2 proteins to regulate the activity of the MAPK signaling complex. Together, our data support a model of integrated self and non-self recognition processes that modulate somatic cell-to-cell communication in N. crassa." @default.
• W2912347299 created "2019-02-21" @default.
• W2912347299 creator A5046220358 @default.
• W2912347299 creator A5056577532 @default.
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• W2912347299 date "2019-02-04" @default.
• W2912347299 modified "2023-09-24" @default.
• W2912347299 title "Integration of Self and Non-self Recognition Modulates Asexual Cell-to-Cell Communication in <i>Neurospora crassa</i>" @default.
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• W2912347299 doi "https://doi.org/10.1534/genetics.118.301780" @default.
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