FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912348619> ?p ?o ?g. }

• W2912348619 endingPage "413" @default.
• W2912348619 startingPage "402" @default.
• W2912348619 abstract "The available drugs for treating Leishmaniasis and American trypanosomiasis have high toxicity and multiple side effects, among other problems. More effective and less toxic treatments are urgently needed. A series of chalcones that contained a prenyloxy or geranyloxy substituent was synthesized and characterized. Each substituent was attached to the A ring in some compounds and to the B ring in others, with additional substituents placed on the chalcone moiety. The present aim was to evaluate the effect of the substitution pattern on leishmanicidal and trypanocidal activity. When tested at a single concentration, the compounds exerting a metabolic inhibition close to or exceeding 50% for Leishmania mexicana were 11, 17 and 12, and for Trypanosoma cruzi were 11, 17, 15 and 26. Upon determining the selectivity index (SI =IC50/CC50), the values were 80.9, 1.24 and 55.12 for 11, 17 and 12 (respectively) versus L. mexicana, and 75.1, 1.43, 27.36 and 33.52 for 11, 17, 15 and 26 (respectively) versus T. cruzi. Structural isomers 11 and 17 showed activity for both the L. mexicana and T. cruzi strains, though the greater cytotoxic activity of 17 led to a lower SI. Compounds 12, 15 and 26 were species specific. For T. cruzi, the SI was higher for 11, 15 and 26 than for the reference drugs nifurtimox and benznidazole. The examination of promastigote morphology after exposing L. mexicana and T. cruzi to 11 revealed a decrease in cell density. The current findings suggest that 11 could be a useful lead compound for further SAR studies." @default.
• W2912348619 created "2019-02-21" @default.
• W2912348619 creator A5045146943 @default.
• W2912348619 creator A5055270807 @default.
• W2912348619 creator A5055313933 @default.
• W2912348619 creator A5055882091 @default.
• W2912348619 creator A5061647793 @default.
• W2912348619 creator A5075993860 @default.
• W2912348619 creator A5086616545 @default.
• W2912348619 date "2019-04-01" @default.
• W2912348619 modified "2023-10-14" @default.
• W2912348619 title "Novel prenyloxy chalcones as potential leishmanicidal and trypanocidal agents: Design, synthesis and evaluation" @default.
• W2912348619 cites W1733625577 @default.
• W2912348619 cites W1969143455 @default.
• W2912348619 cites W1977737534 @default.
• W2912348619 cites W2026652146 @default.
• W2912348619 cites W2033511432 @default.
• W2912348619 cites W2035796563 @default.
• W2912348619 cites W2040336140 @default.
• W2912348619 cites W2041270096 @default.
• W2912348619 cites W2043402164 @default.
• W2912348619 cites W2045728318 @default.
• W2912348619 cites W2048883883 @default.
• W2912348619 cites W2073736511 @default.
• W2912348619 cites W2090642051 @default.
• W2912348619 cites W2120114527 @default.
• W2912348619 cites W2123777722 @default.
• W2912348619 cites W2134531520 @default.
• W2912348619 cites W2139388109 @default.
• W2912348619 cites W2160808854 @default.
• W2912348619 cites W2312494018 @default.
• W2912348619 cites W2320681059 @default.
• W2912348619 cites W2593436234 @default.
• W2912348619 cites W2613820968 @default.
• W2912348619 cites W2729832175 @default.
• W2912348619 cites W2730840378 @default.
• W2912348619 cites W2769322405 @default.
• W2912348619 cites W2808947823 @default.
• W2912348619 cites W2885688891 @default.
• W2912348619 cites W2896850614 @default.
• W2912348619 cites W2951864513 @default.
• W2912348619 cites W4235938477 @default.
• W2912348619 cites W778585144 @default.
• W2912348619 doi "https://doi.org/10.1016/j.ejmech.2019.02.028" @default.
• W2912348619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30784876" @default.
• W2912348619 hasPublicationYear "2019" @default.
• W2912348619 type Work @default.
• W2912348619 sameAs 2912348619 @default.
• W2912348619 citedByCount "20" @default.
• W2912348619 countsByYear W29123486192019 @default.
• W2912348619 countsByYear W29123486192020 @default.
• W2912348619 countsByYear W29123486192021 @default.
• W2912348619 countsByYear W29123486192022 @default.
• W2912348619 countsByYear W29123486192023 @default.
• W2912348619 crossrefType "journal-article" @default.
• W2912348619 hasAuthorship W2912348619A5045146943 @default.
• W2912348619 hasAuthorship W2912348619A5055270807 @default.
• W2912348619 hasAuthorship W2912348619A5055313933 @default.
• W2912348619 hasAuthorship W2912348619A5055882091 @default.
• W2912348619 hasAuthorship W2912348619A5061647793 @default.
• W2912348619 hasAuthorship W2912348619A5075993860 @default.
• W2912348619 hasAuthorship W2912348619A5086616545 @default.
• W2912348619 hasConcept C104317684 @default.
• W2912348619 hasConcept C112418997 @default.
• W2912348619 hasConcept C136764020 @default.
• W2912348619 hasConcept C185592680 @default.
• W2912348619 hasConcept C202751555 @default.
• W2912348619 hasConcept C203014093 @default.
• W2912348619 hasConcept C2776171842 @default.
• W2912348619 hasConcept C2776568683 @default.
• W2912348619 hasConcept C2776635100 @default.
• W2912348619 hasConcept C2776684476 @default.
• W2912348619 hasConcept C2777625466 @default.
• W2912348619 hasConcept C2778689049 @default.
• W2912348619 hasConcept C2779502636 @default.
• W2912348619 hasConcept C2780764945 @default.
• W2912348619 hasConcept C2781049234 @default.
• W2912348619 hasConcept C2781092759 @default.
• W2912348619 hasConcept C2781371782 @default.
• W2912348619 hasConcept C41008148 @default.
• W2912348619 hasConcept C55493867 @default.
• W2912348619 hasConcept C71240020 @default.
• W2912348619 hasConcept C71928629 @default.
• W2912348619 hasConcept C86803240 @default.
• W2912348619 hasConcept C98319499 @default.
• W2912348619 hasConceptScore W2912348619C104317684 @default.
• W2912348619 hasConceptScore W2912348619C112418997 @default.
• W2912348619 hasConceptScore W2912348619C136764020 @default.
• W2912348619 hasConceptScore W2912348619C185592680 @default.
• W2912348619 hasConceptScore W2912348619C202751555 @default.
• W2912348619 hasConceptScore W2912348619C203014093 @default.
• W2912348619 hasConceptScore W2912348619C2776171842 @default.
• W2912348619 hasConceptScore W2912348619C2776568683 @default.
• W2912348619 hasConceptScore W2912348619C2776635100 @default.
• W2912348619 hasConceptScore W2912348619C2776684476 @default.
• W2912348619 hasConceptScore W2912348619C2777625466 @default.
• W2912348619 hasConceptScore W2912348619C2778689049 @default.
• W2912348619 hasConceptScore W2912348619C2779502636 @default.

• next