Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912348784> ?p ?o ?g. }
- W2912348784 abstract "Histone lysine acetylation is critical in regulating transcription. Dysregulation of this process results in aberrant gene expression in various diseases, including cancer. The bromodomain, present in several proteins, recognizes promotor lysine acetylation and recruits other transcription factors. The bromodomain extra-terminal (BET) family of proteins consists of four conserved mammalian members that regulate transcription of oncogenes such as MYC and the NUT fusion oncoprotein. Targeting the acetyl-lysine-binding property of BET proteins is a potential therapeutic approach of cancer. Consequently, following the demonstration that thienotriazolodiazepine small molecules effectively inhibit BET, clinical trials were initiated. We thus discuss the mechanisms of action of various BET inhibitors and the prospects for their clinical use as cancer therapeutics." @default.
- W2912348784 created "2019-02-21" @default.
- W2912348784 creator A5010367275 @default.
- W2912348784 creator A5028396942 @default.
- W2912348784 creator A5031150005 @default.
- W2912348784 creator A5041792736 @default.
- W2912348784 creator A5046995957 @default.
- W2912348784 creator A5055054082 @default.
- W2912348784 creator A5079787243 @default.
- W2912348784 creator A5085151377 @default.
- W2912348784 date "2019-03-01" @default.
- W2912348784 modified "2023-10-16" @default.
- W2912348784 title "Bromodomain and extra-terminal motif inhibitors: a review of preclinical and clinical advances in cancer therapy" @default.
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