FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912348984> ?p ?o ?g. }

• W2912348984 endingPage "70" @default.
• W2912348984 startingPage "66" @default.
• W2912348984 abstract "In Pompe disease, anti-drug antibodies (ADA) to acid alpha-glucosidase (GAA) enzyme replacement therapy contribute to early mortality. Assessing individual risk for ADA development is notoriously difficult in (CRIM-positive) patients expressing endogenous GAA. The individualized T cell epitope measure (iTEM) scoring method predicts patient-specific risk of developing ADA against therapeutic recombinant human GAA (rhGAA) using individualized HLA-binding predictions and GAA genotype. CRIM-negative patients were six times more likely to develop high ADA titers than CRIM-positive patients in this retrospective study, whereas patients with high GAA-iTEM scores were 50 times more likely to develop high ADA titers than patients with low GAA-iTEM scores. This approach identifies high-risk IOPD patients requiring immune tolerance induction therapy to prevent significant ADA response to rhGAA leading to a poor clinical outcome and can assess ADA risk in patients receiving replacement therapy for other enzyme or blood factor deficiency disorders." @default.
• W2912348984 created "2019-02-21" @default.
• W2912348984 creator A5022912096 @default.
• W2912348984 creator A5037775852 @default.
• W2912348984 creator A5048344117 @default.
• W2912348984 creator A5053675979 @default.
• W2912348984 creator A5066351338 @default.
• W2912348984 creator A5067769556 @default.
• W2912348984 creator A5089204881 @default.
• W2912348984 date "2019-03-01" @default.
• W2912348984 modified "2023-10-13" @default.
• W2912348984 title "HLA- and genotype-based risk assessment model to identify infantile onset pompe disease patients at high-risk of developing significant anti-drug antibodies (ADA)" @default.
• W2912348984 cites W1969555423 @default.
• W2912348984 cites W1976548137 @default.
• W2912348984 cites W1978337429 @default.
• W2912348984 cites W2022749609 @default.
• W2912348984 cites W2055655054 @default.
• W2912348984 cites W2055737319 @default.
• W2912348984 cites W2058499405 @default.
• W2912348984 cites W2079778884 @default.
• W2912348984 cites W2091858933 @default.
• W2912348984 cites W2097527799 @default.
• W2912348984 cites W2099289539 @default.
• W2912348984 cites W2100199292 @default.
• W2912348984 cites W2112711488 @default.
• W2912348984 cites W2133992969 @default.
• W2912348984 cites W2143609092 @default.
• W2912348984 cites W2166304356 @default.
• W2912348984 cites W2194998340 @default.
• W2912348984 cites W2268547107 @default.
• W2912348984 cites W2494881046 @default.
• W2912348984 cites W2746547351 @default.
• W2912348984 cites W2944148921 @default.
• W2912348984 cites W2989173305 @default.
• W2912348984 cites W4296259680 @default.
• W2912348984 doi "https://doi.org/10.1016/j.clim.2019.01.009" @default.
• W2912348984 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6554735" @default.
• W2912348984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30711607" @default.
• W2912348984 hasPublicationYear "2019" @default.
• W2912348984 type Work @default.
• W2912348984 sameAs 2912348984 @default.
• W2912348984 citedByCount "14" @default.
• W2912348984 countsByYear W29123489842019 @default.
• W2912348984 countsByYear W29123489842020 @default.
• W2912348984 countsByYear W29123489842021 @default.
• W2912348984 countsByYear W29123489842022 @default.
• W2912348984 countsByYear W29123489842023 @default.
• W2912348984 crossrefType "journal-article" @default.
• W2912348984 hasAuthorship W2912348984A5022912096 @default.
• W2912348984 hasAuthorship W2912348984A5037775852 @default.
• W2912348984 hasAuthorship W2912348984A5048344117 @default.
• W2912348984 hasAuthorship W2912348984A5053675979 @default.
• W2912348984 hasAuthorship W2912348984A5066351338 @default.
• W2912348984 hasAuthorship W2912348984A5067769556 @default.
• W2912348984 hasAuthorship W2912348984A5089204881 @default.
• W2912348984 hasBestOaLocation W29123489841 @default.
• W2912348984 hasConcept C104317684 @default.
• W2912348984 hasConcept C126322002 @default.
• W2912348984 hasConcept C135763542 @default.
• W2912348984 hasConcept C147483822 @default.
• W2912348984 hasConcept C159654299 @default.
• W2912348984 hasConcept C188280979 @default.
• W2912348984 hasConcept C195616568 @default.
• W2912348984 hasConcept C203014093 @default.
• W2912348984 hasConcept C22889606 @default.
• W2912348984 hasConcept C2779134260 @default.
• W2912348984 hasConcept C2779969927 @default.
• W2912348984 hasConcept C2780035454 @default.
• W2912348984 hasConcept C32611913 @default.
• W2912348984 hasConcept C54355233 @default.
• W2912348984 hasConcept C71924100 @default.
• W2912348984 hasConcept C86803240 @default.
• W2912348984 hasConcept C8891405 @default.
• W2912348984 hasConcept C98274493 @default.
• W2912348984 hasConceptScore W2912348984C104317684 @default.
• W2912348984 hasConceptScore W2912348984C126322002 @default.
• W2912348984 hasConceptScore W2912348984C135763542 @default.
• W2912348984 hasConceptScore W2912348984C147483822 @default.
• W2912348984 hasConceptScore W2912348984C159654299 @default.
• W2912348984 hasConceptScore W2912348984C188280979 @default.
• W2912348984 hasConceptScore W2912348984C195616568 @default.
• W2912348984 hasConceptScore W2912348984C203014093 @default.
• W2912348984 hasConceptScore W2912348984C22889606 @default.
• W2912348984 hasConceptScore W2912348984C2779134260 @default.
• W2912348984 hasConceptScore W2912348984C2779969927 @default.
• W2912348984 hasConceptScore W2912348984C2780035454 @default.
• W2912348984 hasConceptScore W2912348984C32611913 @default.
• W2912348984 hasConceptScore W2912348984C54355233 @default.
• W2912348984 hasConceptScore W2912348984C71924100 @default.
• W2912348984 hasConceptScore W2912348984C86803240 @default.
• W2912348984 hasConceptScore W2912348984C8891405 @default.
• W2912348984 hasConceptScore W2912348984C98274493 @default.
• W2912348984 hasLocation W29123489841 @default.
• W2912348984 hasLocation W29123489842 @default.
• W2912348984 hasLocation W29123489843 @default.
• W2912348984 hasLocation W29123489844 @default.
• W2912348984 hasOpenAccess W2912348984 @default.
• W2912348984 hasPrimaryLocation W29123489841 @default.

• next