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- W2912349299 abstract "Introduction: There is limited data addressing the epidemiology of Clostridium difficile infection (CD) in hospitalized patients in the United States (U.S.). This study aims to estimate the demographics, outcomes, and economic burden of patients hospitalized for CD in the US. Methods: The Nationwide Inpatient Sample (NIS) database was used to obtain data from 2000-2014. The NIS contains data from over 7 million hospital stays in the US per year generalizable to the American population. The NIS was queried for ICD-9 codes for primary diagnosis of CD (008.45). Information for demographic data, and hospital charges was evaluated. Results: (Table 1) There were 1,256,783 total discharges from 2000-2014 with CD as the primary diagnosis. The number of hospitalizations with CD as primary diagnosis increased from 31,782 in 2000 to 107,760 in 2014. Aggregate charges increased from $0.51 billion to $3.87 billion annually. The percentage of women admitted for CD was 64.1-66.5% during this period, nearly double that of men admitted. The mean age of patients admitted was between 63.8-68.9. Inpatient mortality for CD decreased from 4.03% in 2005 to 1.67% in 2014.Table: Table. Epidemiology of Clostridium difficile Infection, Nationwide Inpatient Sample, 2000-2014 (Q3 years)Conclusion: This study demonstrates that the number of hospitalizations for CD has increased by 339% from 2000 to 2014. The cost of inpatient care of CD has increased to nearly $4 billion annually. Women are at much increased risk of CD. More research is required to elucidate why women are at a much higher risk of CD. These findings affirm that CD infection is an epidemic that remains a significant source of morbidity and mortality with substantial hospitalization and cost burden. These data can be used to support a return on investment for intervention strategies to prevent the transmission of CD and for new therapies to manage the disease." @default.
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- W2912349299 date "2017-10-01" @default.
- W2912349299 modified "2023-09-24" @default.
- W2912349299 title "Epidemiology of Clostridium difficile Infection in the United States From 2000-2014" @default.
- W2912349299 doi "https://doi.org/10.14309/00000434-201710001-00160" @default.
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