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- W2912353065 endingPage "490" @default.
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- W2912353065 abstract "The function of vascular endothelial growth factor (VEGF) in cancer extends beyond angiogenesis and vascular permeability. Specifically, VEGF-mediated signaling occurs in tumor cells and this signaling contributes to key aspects of tumorigenesis including the self-renewal and survival of cancer stem cells (CSCs). In addition to VEGF receptor tyrosine kinases, the neuropilins (NRPs) are critical for mediating the effects of VEGF on CSCs, primarily because of their ability to impact the function of growth factor receptors and integrins. VEGF/NRP signaling can regulate the expression and function of key molecules that have been implicated in CSC function including Rho family guanosine triphosphatases (GTPases) and transcription factors. The VEGF/NRP signaling axis is a prime target for therapy because it can confer resistance to standard chemotherapy, which is ineffective against most CSCs. Indeed, several studies have shown that targeting either NRP1 or NRP2 can inhibit tumor initiation and decrease resistance to other therapies." @default.
- W2912353065 created "2019-02-21" @default.
- W2912353065 creator A5010527699 @default.
- W2912353065 date "2019-01-23" @default.
- W2912353065 modified "2023-10-17" @default.
- W2912353065 title "VEGF/Neuropilin Signaling in Cancer Stem Cells" @default.
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- W2912353065 doi "https://doi.org/10.3390/ijms20030490" @default.
- W2912353065 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6387347" @default.
- W2912353065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30678134" @default.
- W2912353065 hasPublicationYear "2019" @default.
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