Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912353875> ?p ?o ?g. }
- W2912353875 endingPage "99" @default.
- W2912353875 startingPage "83" @default.
- W2912353875 abstract "Drug development in oncology usually establishes efficacy in metastatic disease before advancing a therapy to the adjuvant or neoadjuvant settings. Unfortunately, too often use in adjuvant or neoadjuvant settings fails to improve overall survival. Reasons for the modest benefits include the fact that in many cases surgery cures a majority of patients making it difficult to demonstrate gains. We begin by looking at the history of adjuvant and neoadjuvant therapies and the principles guiding their development. We summarize accepted adjuvant and neoadjuvant therapies in several cancers and tabulate their outcomes. Then, extending our work on the growth and regression rate constants of tumors and the fraction of cells killed we demonstrate that therapies developed in the metastatic setting primarily delay tumor growth rather than kill more cells and argue this is a likely explanation for poor outcomes in adjuvant or neoadjuvant settings. We suggest a rational approach for enhancing success." @default.
- W2912353875 created "2019-02-21" @default.
- W2912353875 creator A5006092876 @default.
- W2912353875 creator A5013592290 @default.
- W2912353875 creator A5048530943 @default.
- W2912353875 creator A5051429711 @default.
- W2912353875 creator A5074832020 @default.
- W2912353875 date "2019-02-01" @default.
- W2912353875 modified "2023-10-16" @default.
- W2912353875 title "Adjuvant and neoadjuvant cancer therapies: A historical review and a rational approach to understand outcomes" @default.
- W2912353875 cites W1542834205 @default.
- W2912353875 cites W1701849548 @default.
- W2912353875 cites W1828940258 @default.
- W2912353875 cites W1876276942 @default.
- W2912353875 cites W1892756525 @default.
- W2912353875 cites W1909650807 @default.
- W2912353875 cites W1919403884 @default.
- W2912353875 cites W1927722732 @default.
- W2912353875 cites W1929485622 @default.
- W2912353875 cites W1930298597 @default.
- W2912353875 cites W1955397179 @default.
- W2912353875 cites W1961026612 @default.
- W2912353875 cites W1962875322 @default.
- W2912353875 cites W1966182165 @default.
- W2912353875 cites W1973286526 @default.
- W2912353875 cites W1973560717 @default.
- W2912353875 cites W1973808708 @default.
- W2912353875 cites W1983463409 @default.
- W2912353875 cites W1987326983 @default.
- W2912353875 cites W1993797710 @default.
- W2912353875 cites W1996172560 @default.
- W2912353875 cites W2007256480 @default.
- W2912353875 cites W2016791396 @default.
- W2912353875 cites W2026666921 @default.
- W2912353875 cites W2030338862 @default.
- W2912353875 cites W2037339308 @default.
- W2912353875 cites W2043506695 @default.
- W2912353875 cites W2046507292 @default.
- W2912353875 cites W2050319891 @default.
- W2912353875 cites W2055235037 @default.
- W2912353875 cites W2061554699 @default.
- W2912353875 cites W2067787818 @default.
- W2912353875 cites W2072040384 @default.
- W2912353875 cites W2075213874 @default.
- W2912353875 cites W2075894019 @default.
- W2912353875 cites W2080323787 @default.
- W2912353875 cites W2080893371 @default.
- W2912353875 cites W2081278637 @default.
- W2912353875 cites W2086766680 @default.
- W2912353875 cites W2087179076 @default.
- W2912353875 cites W2088551908 @default.
- W2912353875 cites W2095259252 @default.
- W2912353875 cites W2095861620 @default.
- W2912353875 cites W2095865154 @default.
- W2912353875 cites W2096602429 @default.
- W2912353875 cites W2096884232 @default.
- W2912353875 cites W2098276344 @default.
- W2912353875 cites W2098499757 @default.
- W2912353875 cites W2098775844 @default.
- W2912353875 cites W2099088585 @default.
- W2912353875 cites W2101760255 @default.
- W2912353875 cites W2103551875 @default.
- W2912353875 cites W2104504726 @default.
- W2912353875 cites W2108410268 @default.
- W2912353875 cites W2109740395 @default.
- W2912353875 cites W2111199038 @default.
- W2912353875 cites W2111666200 @default.
- W2912353875 cites W2114081348 @default.
- W2912353875 cites W2114264989 @default.
- W2912353875 cites W2115072149 @default.
- W2912353875 cites W2115991409 @default.
- W2912353875 cites W2116780500 @default.
- W2912353875 cites W2118938219 @default.
- W2912353875 cites W2119501407 @default.
- W2912353875 cites W2120661754 @default.
- W2912353875 cites W2122133674 @default.
- W2912353875 cites W2123591186 @default.
- W2912353875 cites W2125620887 @default.
- W2912353875 cites W2125979795 @default.
- W2912353875 cites W2127232551 @default.
- W2912353875 cites W2127395702 @default.
- W2912353875 cites W2127760782 @default.
- W2912353875 cites W2132060393 @default.
- W2912353875 cites W2132352600 @default.
- W2912353875 cites W2133243551 @default.
- W2912353875 cites W2134421056 @default.
- W2912353875 cites W2135636495 @default.
- W2912353875 cites W2135800076 @default.
- W2912353875 cites W2136802843 @default.
- W2912353875 cites W2138440511 @default.
- W2912353875 cites W2138582833 @default.
- W2912353875 cites W2139280622 @default.
- W2912353875 cites W2139510434 @default.
- W2912353875 cites W2140354367 @default.
- W2912353875 cites W2141665958 @default.
- W2912353875 cites W2141768150 @default.
- W2912353875 cites W2143596381 @default.
- W2912353875 cites W2144495943 @default.