FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912354873> ?p ?o ?g. }

• W2912354873 abstract "Object: Acute leukemia is the most common malignancy in children. Despite recent therapeutic advances patients with relapsed or refractory disease require new treatment options. While synthetic immunotherapies such as chimeric antigen receptor (CAR) T-cells have shown impressive efficacy in B-precursor acute lymphoblastic leukemia (BCP-ALL) patients, the interaction between leukemic blasts and bone marrow T-cells remains largely unknown. Therefore, the role for immune response amplifiers in leukemia patients is currently unclear. Leukemia outgrowth leads to low frequency of physiologic bone marrow populations such as T-cells. Those T-cells are consequently within the site of tumor development and can thus be defined as tumor-infiltrating lymphocytes (TILs). Dysfunction of TILs has been described in a variety of solid and in some hematologic malignancies. To determine the changes driven by leukemia blasts we analyzed T-cells in bone marrow samples from pediatric patients with BCP-ALL, T-precursor ALL (TCP-ALL) and acute myelogenous leukemia (AML) at the time of diagnosis and relapse in comparison to healthy bone marrow donors. Material and Methods: In pilot experiments, any artificial changes in marker expression due to cryopreservation and thawing were excluded (n=5). Then, cryopreserved bone marrow samples from both pediatric patients with acute leukemia (n= 77; BCP-ALL: 18, TCP-ALL: 23, AML: 36) and age-matched healthy bone marrow donors (n=23) were identified in our local biobank. Multicolor flow cytometry was performed to quantify co-inhibitory markers on CD4 and CD8 T-cells in primary (n=49) and relapse leukemia samples (n=28). Results: The frequency of bone marrow T-cells was reduced in patients with acute leukemia in comparison with healthy controls (5.9% vs. 24.4%, mean values, p primary > healthy). These findings could reflect insufficient immune surveillance of pediatric leukemia by bone marrow T-cells and may provide a rationale for future therapeutic interventions. Citation Format: Semjon Manuel Willier, Paula Rothaemel, Jonas Wilhelm, Dana Stenger, Theresa Kauferle, Irene Schmid, Michael H. Albert, Vera Binder, Franziska Blaeschke, Tobias Feuchtinger. Bone marrow T-cells are tumor-infiltrating T-cells in pediatric patients with acute leukemia and their phenotype reflects immune evasion of leukemic blasts [abstract]. In: Proceedings of the Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; Sept 30-Oct 3, 2018; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2019;7(2 Suppl):Abstract nr A224." @default.
• W2912354873 created "2019-02-21" @default.
• W2912354873 creator A5020207883 @default.
• W2912354873 creator A5027350146 @default.
• W2912354873 creator A5030851924 @default.
• W2912354873 creator A5046653102 @default.
• W2912354873 creator A5055645533 @default.
• W2912354873 creator A5059831431 @default.
• W2912354873 creator A5064628032 @default.
• W2912354873 creator A5068049269 @default.
• W2912354873 creator A5084382516 @default.
• W2912354873 creator A5089589180 @default.
• W2912354873 date "2019-02-01" @default.
• W2912354873 modified "2023-10-14" @default.
• W2912354873 title "Abstract A224: Bone marrow T-cells are tumor-infiltrating T-cells in pediatric patients with acute leukemia and their phenotype reflects immune evasion of leukemic blasts" @default.
• W2912354873 doi "https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a224" @default.
• W2912354873 hasPublicationYear "2019" @default.
• W2912354873 type Work @default.
• W2912354873 sameAs 2912354873 @default.
• W2912354873 citedByCount "0" @default.
• W2912354873 crossrefType "proceedings-article" @default.
• W2912354873 hasAuthorship W2912354873A5020207883 @default.
• W2912354873 hasAuthorship W2912354873A5027350146 @default.
• W2912354873 hasAuthorship W2912354873A5030851924 @default.
• W2912354873 hasAuthorship W2912354873A5046653102 @default.
• W2912354873 hasAuthorship W2912354873A5055645533 @default.
• W2912354873 hasAuthorship W2912354873A5059831431 @default.
• W2912354873 hasAuthorship W2912354873A5064628032 @default.
• W2912354873 hasAuthorship W2912354873A5068049269 @default.
• W2912354873 hasAuthorship W2912354873A5084382516 @default.
• W2912354873 hasAuthorship W2912354873A5089589180 @default.
• W2912354873 hasConcept C147483822 @default.
• W2912354873 hasConcept C196166836 @default.
• W2912354873 hasConcept C203014093 @default.
• W2912354873 hasConcept C2776863199 @default.
• W2912354873 hasConcept C2777701055 @default.
• W2912354873 hasConcept C2778461978 @default.
• W2912354873 hasConcept C2780007613 @default.
• W2912354873 hasConcept C502942594 @default.
• W2912354873 hasConcept C71924100 @default.
• W2912354873 hasConcept C8891405 @default.
• W2912354873 hasConceptScore W2912354873C147483822 @default.
• W2912354873 hasConceptScore W2912354873C196166836 @default.
• W2912354873 hasConceptScore W2912354873C203014093 @default.
• W2912354873 hasConceptScore W2912354873C2776863199 @default.
• W2912354873 hasConceptScore W2912354873C2777701055 @default.
• W2912354873 hasConceptScore W2912354873C2778461978 @default.
• W2912354873 hasConceptScore W2912354873C2780007613 @default.
• W2912354873 hasConceptScore W2912354873C502942594 @default.
• W2912354873 hasConceptScore W2912354873C71924100 @default.
• W2912354873 hasConceptScore W2912354873C8891405 @default.
• W2912354873 hasLocation W29123548731 @default.
• W2912354873 hasOpenAccess W2912354873 @default.
• W2912354873 hasPrimaryLocation W29123548731 @default.
• W2912354873 hasRelatedWork W147903966 @default.
• W2912354873 hasRelatedWork W1515744967 @default.
• W2912354873 hasRelatedWork W2235057538 @default.
• W2912354873 hasRelatedWork W2353683318 @default.
• W2912354873 hasRelatedWork W2357365628 @default.
• W2912354873 hasRelatedWork W2364084648 @default.
• W2912354873 hasRelatedWork W2461965637 @default.
• W2912354873 hasRelatedWork W2601388288 @default.
• W2912354873 hasRelatedWork W3117415196 @default.
• W2912354873 hasRelatedWork W3126351143 @default.
• W2912354873 isParatext "false" @default.
• W2912354873 isRetracted "false" @default.
• W2912354873 magId "2912354873" @default.
• W2912354873 workType "article" @default.