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- W2912355191 abstract "To compare the incidence of childhood cancer in children born from assisted reproductive technology (ART) to the general population. Longitudinal cohort of children in 14 States (CA, CO, CT, FL, IL, MA, MI, NC, NJ, NY, OH, PA, TX, and VA). Women who were residents of participating study States and who underwent in vitro fertilization cycles resulting in a live birth between 2004 and 2013 (three States to 2009 and one State to 2010) were linked to their birth certificates; 10:1 random sample of births from non-ART deliveries were selected as controls. All children were linked to their respective State cancer registries through 2013 (three States through 2012); additional data are expected from one State. Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CI) of the risk of cancer in children conceived by ART versus controls, adjusting for State and year of birth, and mother’s age, race, and education, stratified by plurality. Controls were compared to all ART births, to those using fresh embryos and to those using thawed embryos. The study included 2,275,341 children with 2,142 cancers, including 204,655 ART children with 242 cancers. The singleton HR for ART births using fresh embryos was marginally increased relative to controls, but not increased using thawed embryos. The HR confidence intervals for twins included the estimates for singletons, indicating no statistical difference between the two groups. This large study shows that the potential increases in cancer rates among ART children are small. However, these results warrant further surveillance and continued research into the association between ART treatment and cancer.Tabled 1N, ChildrenN, CancersRate/1,000 BirthsHazard Ratio95% CIp-ValueSingletonsControls2,005,7921,8430.921.00Reference--All ART114,8621321.151.170.97, 1.410.102Fresh ART90,2431111.231.220.99, 1.490.054Thawed ART24,619210.850.950.61, 1.470.804TwinsControls64,894570.881.00Reference--All ART89,7931101.231.160.18, 1.680.41Fresh ART75,389891.181.090.75, 1.590.65Thawed ART14,404211.461.550.87, 2.760.13 Open table in a new tab" @default.
- W2912355191 created "2019-02-21" @default.
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- W2912355191 date "2017-09-01" @default.
- W2912355191 modified "2023-10-18" @default.
- W2912355191 title "Assisted reproductive technology & risk of childhood cancer" @default.
- W2912355191 doi "https://doi.org/10.1016/j.fertnstert.2017.07.170" @default.
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