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- W2912358765 abstract "Pleural infection managed with intrapleural therapy using a combination of 10 mg of tissue plasminogen activator (tPA) and 5 mg of deoxyribonuclease (DNase) has been shown in randomized and open‐label studies to successfully treat >90% of patients without resorting to surgery. Potential bleeding risks, although low, and costs associated with tPA remain important concerns. No phase I studies exist for intrapleural tPA therapy and the lowest effective dose has not been established. In patients with high bleeding risks, lower doses may present a safer alternative. We report a case of a complex parapneumonic effusion in a patient with coagulopathy that was successfully treated with a very low dose tPA (1 mg) and DNase (5 mg) regime." @default.
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- W2912358765 date "2019-02-13" @default.
- W2912358765 modified "2023-10-06" @default.
- W2912358765 title "Successful management of pleural infection with very low dose intrapleural tissue plasminogen activator/deoxyribonuclease regime" @default.
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- W2912358765 doi "https://doi.org/10.1002/rcr2.408" @default.
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