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- W2912360054 abstract "Abstract We constructed a standardized protein folding kinetics database (PFDB) in which the logarithmic rate constants of all listed proteins are calculated at the standard temperature (25 °C). A temperature correction based on the Eyring–Kramers equation was introduced for proteins whose folding kinetics were originally measured at temperatures other than 25 °C. We verified the temperature correction by comparing the logarithmic rate constants predicted and experimentally observed at 25 °C for 14 different proteins, and the results demonstrated improvement of the quality of the database. PFDB consists of 141 (89 two-state and 52 non-two-state) single-domain globular proteins, which has the largest number among the currently available databases of protein folding kinetics. PFDB is thus intended to be used as a standard for developing and testing future predictive and theoretical studies of protein folding. PFDB can be accessed from the following link: http://lee.kias.re.kr/~bala/PFDB ." @default.
- W2912360054 created "2019-02-21" @default.
- W2912360054 creator A5040180866 @default.
- W2912360054 creator A5052434732 @default.
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- W2912360054 date "2019-02-07" @default.
- W2912360054 modified "2023-10-18" @default.
- W2912360054 title "PFDB: A standardized protein folding database with temperature correction" @default.
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- W2912360054 doi "https://doi.org/10.1038/s41598-018-36992-y" @default.
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