FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912361025> ?p ?o ?g. }

• W2912361025 endingPage "51" @default.
• W2912361025 startingPage "37" @default.
• W2912361025 abstract "The excessive activation of interferon regulatory factor 7 (IRF7) promotes the development of acute lung injury (ALI) caused by influenza A virus (IAV). However, the deficiency of IRF7 increases the susceptibility to deadly IAV infection in both humans and mice. To test whether the attenuation rather than the abolishment of IRF7 activity in local infectious sites could alleviate IAV-induced ALI, we established IAV-infected mouse model and trachea/lung-tissue culture systems, and designed two IRF7-interfering oligodeoxynucleotides, IRF7-rODN M1 and IRF7-rODN A1, based on the mouse and human consensus sequences of IRF7-binding sites of Ifna/IFNA genes, respectively. In the model mice, we found a close relationship between the IAV-induced ALI and the level/activity of IRF7 in local infectious sites, and also found that the reduced IRF7 level or activity in the lungs of mice treated with IRF7-rODN M1 led to decreased mRNA levels of Ifna genes, reduced neutrophil infiltration in the lungs and prolonged survival of mice. Furthermore, we found that the effects of IRF7-rODN M1 on alleviating IAV-induced ALI could be correlated to the reduced translocation of IRF7, caused by the IRF7-rODN M1, from cytosol to nucleus in IAV-infected cells. These data suggest that the proper attenuation of IRF7 activity in local infectious sites could be a novel approach for treating IAV-induced ALI." @default.
• W2912361025 created "2019-02-21" @default.
• W2912361025 creator A5015832602 @default.
• W2912361025 creator A5016806891 @default.
• W2912361025 creator A5017651819 @default.
• W2912361025 creator A5017917541 @default.
• W2912361025 creator A5018863416 @default.
• W2912361025 creator A5021653618 @default.
• W2912361025 creator A5028817447 @default.
• W2912361025 creator A5041245898 @default.
• W2912361025 creator A5048471911 @default.
• W2912361025 creator A5054352703 @default.
• W2912361025 date "2019-02-27" @default.
• W2912361025 modified "2023-10-16" @default.
• W2912361025 title "Attenuation of interferon regulatory factor 7 activity in local infectious sites of trachea and lung for preventing the development of acute lung injury caused by influenza A virus" @default.
• W2912361025 cites W126601421 @default.
• W2912361025 cites W1578945147 @default.
• W2912361025 cites W1966991165 @default.
• W2912361025 cites W1974796764 @default.
• W2912361025 cites W1977853360 @default.
• W2912361025 cites W1978090289 @default.
• W2912361025 cites W1978131385 @default.
• W2912361025 cites W1978990512 @default.
• W2912361025 cites W1979882857 @default.
• W2912361025 cites W1982120218 @default.
• W2912361025 cites W1983483525 @default.
• W2912361025 cites W1985056697 @default.
• W2912361025 cites W1994185516 @default.
• W2912361025 cites W2003474402 @default.
• W2912361025 cites W2005884645 @default.
• W2912361025 cites W2006406228 @default.
• W2912361025 cites W2007999467 @default.
• W2912361025 cites W2011678998 @default.
• W2912361025 cites W2020464368 @default.
• W2912361025 cites W2021770916 @default.
• W2912361025 cites W2031913105 @default.
• W2912361025 cites W2034915145 @default.
• W2912361025 cites W2045078709 @default.
• W2912361025 cites W2058039642 @default.
• W2912361025 cites W2071688420 @default.
• W2912361025 cites W2072862372 @default.
• W2912361025 cites W2074474415 @default.
• W2912361025 cites W2074600973 @default.
• W2912361025 cites W2076026689 @default.
• W2912361025 cites W2083162205 @default.
• W2912361025 cites W2084880831 @default.
• W2912361025 cites W2085459501 @default.
• W2912361025 cites W2091129202 @default.
• W2912361025 cites W2110812524 @default.
• W2912361025 cites W2115528382 @default.
• W2912361025 cites W2123197974 @default.
• W2912361025 cites W2169316855 @default.
• W2912361025 cites W2209535043 @default.
• W2912361025 cites W2301069603 @default.
• W2912361025 cites W2523423453 @default.
• W2912361025 cites W2528722070 @default.
• W2912361025 cites W2547765422 @default.
• W2912361025 cites W2557403528 @default.
• W2912361025 cites W2591587054 @default.
• W2912361025 cites W2592260836 @default.
• W2912361025 cites W2601540892 @default.
• W2912361025 cites W2612411445 @default.
• W2912361025 cites W2771256621 @default.
• W2912361025 cites W2783439885 @default.
• W2912361025 cites W2789519809 @default.
• W2912361025 cites W2791709730 @default.
• W2912361025 doi "https://doi.org/10.1111/imm.13045" @default.
• W2912361025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6459777" @default.
• W2912361025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30667045" @default.
• W2912361025 hasPublicationYear "2019" @default.
• W2912361025 type Work @default.
• W2912361025 sameAs 2912361025 @default.
• W2912361025 citedByCount "14" @default.
• W2912361025 countsByYear W29123610252020 @default.
• W2912361025 countsByYear W29123610252021 @default.
• W2912361025 countsByYear W29123610252022 @default.
• W2912361025 countsByYear W29123610252023 @default.
• W2912361025 crossrefType "journal-article" @default.
• W2912361025 hasAuthorship W2912361025A5015832602 @default.
• W2912361025 hasAuthorship W2912361025A5016806891 @default.
• W2912361025 hasAuthorship W2912361025A5017651819 @default.
• W2912361025 hasAuthorship W2912361025A5017917541 @default.
• W2912361025 hasAuthorship W2912361025A5018863416 @default.
• W2912361025 hasAuthorship W2912361025A5021653618 @default.
• W2912361025 hasAuthorship W2912361025A5028817447 @default.
• W2912361025 hasAuthorship W2912361025A5041245898 @default.
• W2912361025 hasAuthorship W2912361025A5048471911 @default.
• W2912361025 hasAuthorship W2912361025A5054352703 @default.
• W2912361025 hasBestOaLocation W29123610251 @default.
• W2912361025 hasConcept C104317684 @default.
• W2912361025 hasConcept C126322002 @default.
• W2912361025 hasConcept C136449434 @default.
• W2912361025 hasConcept C203014093 @default.
• W2912361025 hasConcept C2776178377 @default.
• W2912361025 hasConcept C2776966659 @default.
• W2912361025 hasConcept C2777714996 @default.
• W2912361025 hasConcept C2780209191 @default.
• W2912361025 hasConcept C32300475 @default.

• next