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• W2912361180 abstract "We examined associations between cognitive reserve and late-life amyloid-β deposition using florbetapir positron emission tomography (PET). We used data from the Atherosclerosis Risk in Communities (ARIC) and ARIC-PET Study. 330 dementia-free participants underwent PET scans. Mean global cortical s tandardized uptake value ratio (SUVR) >1.2 was defined as elevated. Midlife cognition was significantly associated with late-life cognition, but not with late-life elevated SUVR; education was not associated with late-life SUVR, but was strongly associated with late-life cognition. Cognitive reserve may reduce dementia risk by mitigating the impact of Alzheimer’s disease pathology on the clinical expression of dementia, rather than by altering its pathogenesis." @default.
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• W2912361180 date "2019-03-29" @default.
• W2912361180 modified "2023-10-12" @default.
• W2912361180 title "Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life" @default.
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• W2912361180 doi "https://doi.org/10.3233/jad-180785" @default.
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