Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912361307> ?p ?o ?g. }
- W2912361307 abstract "Abstract Baicalin is a natural compound isolated from Chinese herb, which has been reported as an anti-inflammatory drug. Here, we demonstrated that Baicalin treatment could reduce urine protein, inhibit anti-ds-DNA antibody titers, and ameliorate lupus nephritis in MRL/lpr lupus-prone mice. Baicalin inhibited Tfh cell differentiation and IL-21 production, but promoted Foxp3 + regulatory T cell differentiation including part of follicular regulatory T (Tfr) cells. Intravenous injection of Baicalin-induced Foxp3 + regulatory T cells could relieve nephritis, inhibit Tfh cell differentiation and IL-21 production. Baicalin inhibited mTOR activation, reduced mTOR agonist-mediated Tfh cell expansion and increased Tfr cells. These data suggest that Baicalin attenuates lupus autoimmunity by up- and downregulating the differentiation of Tfr cells and Tfh cells, respectively. Baicalin and ex vivo expanded Foxp3 + regulatory T cells are promising therapeutics for the treatment of lupus." @default.
- W2912361307 created "2019-02-21" @default.
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- W2912361307 date "2019-02-13" @default.
- W2912361307 modified "2023-10-13" @default.
- W2912361307 title "Baicalin ameliorates lupus autoimmunity by inhibiting differentiation of Tfh cells and inducing expansion of Tfr cells" @default.
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- W2912361307 doi "https://doi.org/10.1038/s41419-019-1315-9" @default.
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