FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912362473> ?p ?o ?g. }

• W2912362473 endingPage "182" @default.
• W2912362473 startingPage "175" @default.
• W2912362473 abstract "Evidence is lacking regarding whether vaginal pre-exposure prophylaxis with topical tenofovir (TFV) reduces the risk of rectal HIV acquisition.Bronx, NY.MTN-014 was a phase 1, cross-over, randomized sequence trial comparing the cross-compartment pharmacokinetics and pharmacodynamics of daily TFV reduced-glycerin 1% gel after 14 days each of rectal and vaginal application, with directly observed dosing and a 6-week washout period between phases.Fourteen HIV-uninfected women enrolled; 91% of doses were observed and 13 women completed all study procedures. TFV and TFV diphosphate (TFV-DP) were detected in most samples collected from the dosing compartment. After vaginal dosing, TFV was detected in 10/14 samples of rectal fluid (RF) (median 4.4 ng/sponge) and 1/13 rectal tissue samples (0.2 ng/mg); TFV-DP was detected in 2/13 rectal tissue samples at 59.8 and 76.5 fmol/mg. After rectal dosing, TFV was detected in 9/14 samples of vaginal fluid (median 1.1 ng/swab) and in 6/14 vaginal tissue samples (median below limit of quantification); TFV-DP was detected in 3/14 vaginal tissue samples at 17.3, 87.6, and 77.1 fmol/mg. Neither cervicovaginal lavage fluid nor RF collected 24 hours after rectal or vaginal dosing resulted in a statistically significant suppression of viral replication.In this study of 14 days each of vaginal and rectal application of TFV reduced-glycerin 1% gel, we found only a small degree of cross-compartment distribution of TFV in RF and vaginal fluids and no pharmacodynamic activity in ex vivo testing. Although high TFV concentrations in the dosing compartment may be protective, low cross-compartment tissue concentrations are not likely to be protective." @default.
• W2912362473 created "2019-02-21" @default.
• W2912362473 creator A5008353750 @default.
• W2912362473 creator A5009903397 @default.
• W2912362473 creator A5023559430 @default.
• W2912362473 creator A5028238434 @default.
• W2912362473 creator A5037374756 @default.
• W2912362473 creator A5039892070 @default.
• W2912362473 creator A5053567182 @default.
• W2912362473 creator A5057936512 @default.
• W2912362473 creator A5063158307 @default.
• W2912362473 creator A5064322463 @default.
• W2912362473 creator A5067182786 @default.
• W2912362473 creator A5076589614 @default.
• W2912362473 creator A5082007029 @default.
• W2912362473 creator A5085639427 @default.
• W2912362473 creator A5086142193 @default.
• W2912362473 creator A5089253859 @default.
• W2912362473 date "2018-06-01" @default.
• W2912362473 modified "2023-10-18" @default.
• W2912362473 title "Pharmacokinetics and Pharmacodynamics of Tenofovir Reduced-Glycerin 1% Gel in the Rectal and Vaginal Compartments in Women: A Cross-Compartmental Study With Directly Observed Dosing" @default.
• W2912362473 cites W128383633 @default.
• W2912362473 cites W1895220657 @default.
• W2912362473 cites W1917043471 @default.
• W2912362473 cites W1967059888 @default.
• W2912362473 cites W1977176987 @default.
• W2912362473 cites W1986961603 @default.
• W2912362473 cites W1994842809 @default.
• W2912362473 cites W1999988675 @default.
• W2912362473 cites W2003864666 @default.
• W2912362473 cites W2009896014 @default.
• W2912362473 cites W2011600333 @default.
• W2912362473 cites W2015636840 @default.
• W2912362473 cites W2036717284 @default.
• W2912362473 cites W2042528340 @default.
• W2912362473 cites W2044369525 @default.
• W2912362473 cites W2047154690 @default.
• W2912362473 cites W2069582117 @default.
• W2912362473 cites W2077097712 @default.
• W2912362473 cites W2077192472 @default.
• W2912362473 cites W2095844669 @default.
• W2912362473 cites W2103920597 @default.
• W2912362473 cites W2111074424 @default.
• W2912362473 cites W2117057469 @default.
• W2912362473 cites W2143190397 @default.
• W2912362473 cites W2146634980 @default.
• W2912362473 cites W2146939936 @default.
• W2912362473 cites W2161496228 @default.
• W2912362473 cites W2162226934 @default.
• W2912362473 cites W2162615263 @default.
• W2912362473 cites W2326890844 @default.
• W2912362473 cites W2540893967 @default.
• W2912362473 cites W2619565046 @default.
• W2912362473 cites W319043714 @default.
• W2912362473 doi "https://doi.org/10.1097/qai.0000000000001655" @default.
• W2912362473 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5963717" @default.
• W2912362473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29767639" @default.
• W2912362473 hasPublicationYear "2018" @default.
• W2912362473 type Work @default.
• W2912362473 sameAs 2912362473 @default.
• W2912362473 citedByCount "10" @default.
• W2912362473 countsByYear W29123624732018 @default.
• W2912362473 countsByYear W29123624732020 @default.
• W2912362473 countsByYear W29123624732021 @default.
• W2912362473 countsByYear W29123624732022 @default.
• W2912362473 countsByYear W29123624732023 @default.
• W2912362473 crossrefType "journal-article" @default.
• W2912362473 hasAuthorship W2912362473A5008353750 @default.
• W2912362473 hasAuthorship W2912362473A5009903397 @default.
• W2912362473 hasAuthorship W2912362473A5023559430 @default.
• W2912362473 hasAuthorship W2912362473A5028238434 @default.
• W2912362473 hasAuthorship W2912362473A5037374756 @default.
• W2912362473 hasAuthorship W2912362473A5039892070 @default.
• W2912362473 hasAuthorship W2912362473A5053567182 @default.
• W2912362473 hasAuthorship W2912362473A5057936512 @default.
• W2912362473 hasAuthorship W2912362473A5063158307 @default.
• W2912362473 hasAuthorship W2912362473A5064322463 @default.
• W2912362473 hasAuthorship W2912362473A5067182786 @default.
• W2912362473 hasAuthorship W2912362473A5076589614 @default.
• W2912362473 hasAuthorship W2912362473A5082007029 @default.
• W2912362473 hasAuthorship W2912362473A5085639427 @default.
• W2912362473 hasAuthorship W2912362473A5086142193 @default.
• W2912362473 hasAuthorship W2912362473A5089253859 @default.
• W2912362473 hasBestOaLocation W29123624731 @default.
• W2912362473 hasConcept C111113717 @default.
• W2912362473 hasConcept C111368507 @default.
• W2912362473 hasConcept C112705442 @default.
• W2912362473 hasConcept C126322002 @default.
• W2912362473 hasConcept C127313418 @default.
• W2912362473 hasConcept C203635412 @default.
• W2912362473 hasConcept C2776873419 @default.
• W2912362473 hasConcept C2777288759 @default.
• W2912362473 hasConcept C42219234 @default.
• W2912362473 hasConcept C71924100 @default.
• W2912362473 hasConceptScore W2912362473C111113717 @default.
• W2912362473 hasConceptScore W2912362473C111368507 @default.
• W2912362473 hasConceptScore W2912362473C112705442 @default.
• W2912362473 hasConceptScore W2912362473C126322002 @default.

• next