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• W2912363239 abstract "Abstract To examine the association between metabolic deregulation and pancreatic cancer, we conducted a two-stage case–control targeted metabolomics study using prediagnostic sera collected one year before diagnosis in the Women's Health Initiative study. We used the LC/MS to quantitate 470 metabolites in 30 matched case/control pairs. From 180 detectable metabolites, we selected 14 metabolites to be validated in additional 18 matched case/control pairs. We used the paired t test to compare the concentrations of each metabolite between cases and controls and used the log fold change (FC) to indicate the magnitude of difference. FDR adjusted q-value &lt; 0.25 was indicated statistically significant. Logistic regression model and ROC curve analysis were used to evaluate the clinical utility of the metabolites. Among 30 case/control pairs, 1-methyl-l-tryptophan (L-1MT) was significantly lower in the cases than in the controls (log2 FC = −0.35; q-value = 0.03). The area under the ROC curve was 0.83 in the discrimination analysis based on the levels of L-1MT, acadesine, and aspartic acid. None of the metabolites was validated in additional independent 18 case/control pairs. No significant association was found between the examined metabolites and undiagnosed pancreatic cancer." @default.
• W2912363239 created "2019-02-21" @default.
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• W2912363239 date "2019-04-01" @default.
• W2912363239 modified "2023-10-18" @default.
• W2912363239 title "A Prospective Targeted Serum Metabolomics Study of Pancreatic Cancer in Postmenopausal Women" @default.
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• W2912363239 doi "https://doi.org/10.1158/1940-6207.capr-18-0201" @default.
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