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• W2912365070 abstract "Background Human milk is an important carrier of PCBs and lactational transfer represents the primary route of PCB exposure to developing mammals. A measure of exposure of infants is the amount taken up into the body, commonly considered to be a product of the concentration of the compound in milk and the rate of consumption of breast milk or alternately duration of breast feeding. This approach is accompanied by many uncertainties originating from reporting on duration and exclusivity of breast feeding. Aims To create a valid relationship between concentration of PCB 153 in serum of breast fed infant and duration of breast feeding and to minimalize the influence of uncertainties in the reported data. Methods We started from data on lipid adjusted PCB 153 serum concentration in the following time intervals after birth: 0, 6, 16, 45 and 72 months and on maternal PCB 153 serum concentration at delivery. We included into the study 305 births during the period 2002-2003 from Michalovce districts in eastern Slovakia, an area polluted by PCBs. Serum PCB 153 concentration and breast feeding duration data were fed into a 4 parameter model approximating the concentration-time profile as described earlier (Trnovec T, et al. Chemosphere. 2011, 85:1687-93). Results The relationship between duration of breast feeding and PCB 153 serum concentration of the infant was described by a modified 3 parameters Weibull function. The PCB 153 serum concentration at termination of breast feeding was adjusted to PCB 153 concentration in cord blood serum to eliminate variability due to prenatal exposure. The postnatal PCB 153 serum concentration time course typically peaked when breast feeding ended which helped to discover discrepancies between real and data reported by mother on breast feeding period. Conclusions Our approach makes possible to predict reliably the PCB 153 concentration in infant’s serum adjusted to cord blood concentration from breast feeding duration." @default.
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• W2912365070 date "2013-09-19" @default.
• W2912365070 modified "2023-10-17" @default.
• W2912365070 title "Novel approach to assessment of infant exposure to PCB 153 resulting from breast feeding" @default.
• W2912365070 doi "https://doi.org/10.1289/isee.2013.p-1-22-17" @default.
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