Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912367139> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2912367139 endingPage "254" @default.
- W2912367139 startingPage "251" @default.
- W2912367139 abstract "Introduction. Myelodysplastic/myeloproliferative neoplasms represent a group of rare hematologic malignancies with concomitant characteristics of two different disorders. There are cytopenias and cytoses with dysplastic morphology in the circulating blood and hyperplastic bone marrow, respectively. Many cytogenetic and molecular features have been found in this rare entity, but t(2;11)(p21;q23)del(5) (q22;q33) has not been described so far. Case report. We present a patient with myelodysplastic syndrome, subtype refractory anemia without ringed sideroblasts, with unique translocation t(2;11)(p21;q23) associated with del(5)(q22;q33) in the karyotype. Fluorescence in situ hybridization analysis did not detect mixed-lineage leukemia (MLL) rearrangement, which can be found in other hematologic malignancies with this translocation. After a year on supportive treatment with packed red cells, thrombocytosis developed with a concurrent increase in white blood cells and the Janus kinase-2 gene mutation. This confirmed the presence of myelodysplastic/myeloproliferative neoplasms. Due to the high platelet count, the cerebrovascular insult has occurred. The patient was treated supportively and with lenalidomide. After introducing the lenalidomide steadily, the patient?s condition improved, the peripheral blood count normalized, and he became transfusion independent. Conclusion. Patients with the cytogenetic finding of t(2;11)(p21;q23) associated with del(5)(q22;q33) but without MLL rearrangement and with Ja-nus kinase-2 gene mutation presence, respond to lenalidomide therapy and have relatively longer overall survival." @default.
- W2912367139 created "2019-02-21" @default.
- W2912367139 creator A5001617369 @default.
- W2912367139 creator A5016425305 @default.
- W2912367139 creator A5048897409 @default.
- W2912367139 creator A5056545510 @default.
- W2912367139 creator A5072515292 @default.
- W2912367139 date "2021-01-01" @default.
- W2912367139 modified "2023-09-25" @default.
- W2912367139 title "Myelodysplastic/myeloproliferative neoplasm with t(2;11)(p21;q23)del(5) (q22;q33) but without mixed-lineage leukemia (MLL) rearrangement" @default.
- W2912367139 doi "https://doi.org/10.2298/vsp190127011c" @default.
- W2912367139 hasPublicationYear "2021" @default.
- W2912367139 type Work @default.
- W2912367139 sameAs 2912367139 @default.
- W2912367139 citedByCount "0" @default.
- W2912367139 crossrefType "journal-article" @default.
- W2912367139 hasAuthorship W2912367139A5001617369 @default.
- W2912367139 hasAuthorship W2912367139A5016425305 @default.
- W2912367139 hasAuthorship W2912367139A5048897409 @default.
- W2912367139 hasAuthorship W2912367139A5056545510 @default.
- W2912367139 hasAuthorship W2912367139A5072515292 @default.
- W2912367139 hasBestOaLocation W29123671391 @default.
- W2912367139 hasConcept C104317684 @default.
- W2912367139 hasConcept C126322002 @default.
- W2912367139 hasConcept C138626823 @default.
- W2912367139 hasConcept C142724271 @default.
- W2912367139 hasConcept C2776063141 @default.
- W2912367139 hasConcept C2776364478 @default.
- W2912367139 hasConcept C2777542201 @default.
- W2912367139 hasConcept C2778461978 @default.
- W2912367139 hasConcept C2779788118 @default.
- W2912367139 hasConcept C2780007613 @default.
- W2912367139 hasConcept C2780076729 @default.
- W2912367139 hasConcept C2780817109 @default.
- W2912367139 hasConcept C2781107747 @default.
- W2912367139 hasConcept C30481170 @default.
- W2912367139 hasConcept C502942594 @default.
- W2912367139 hasConcept C54355233 @default.
- W2912367139 hasConcept C71924100 @default.
- W2912367139 hasConcept C86803240 @default.
- W2912367139 hasConcept C89560881 @default.
- W2912367139 hasConceptScore W2912367139C104317684 @default.
- W2912367139 hasConceptScore W2912367139C126322002 @default.
- W2912367139 hasConceptScore W2912367139C138626823 @default.
- W2912367139 hasConceptScore W2912367139C142724271 @default.
- W2912367139 hasConceptScore W2912367139C2776063141 @default.
- W2912367139 hasConceptScore W2912367139C2776364478 @default.
- W2912367139 hasConceptScore W2912367139C2777542201 @default.
- W2912367139 hasConceptScore W2912367139C2778461978 @default.
- W2912367139 hasConceptScore W2912367139C2779788118 @default.
- W2912367139 hasConceptScore W2912367139C2780007613 @default.
- W2912367139 hasConceptScore W2912367139C2780076729 @default.
- W2912367139 hasConceptScore W2912367139C2780817109 @default.
- W2912367139 hasConceptScore W2912367139C2781107747 @default.
- W2912367139 hasConceptScore W2912367139C30481170 @default.
- W2912367139 hasConceptScore W2912367139C502942594 @default.
- W2912367139 hasConceptScore W2912367139C54355233 @default.
- W2912367139 hasConceptScore W2912367139C71924100 @default.
- W2912367139 hasConceptScore W2912367139C86803240 @default.
- W2912367139 hasConceptScore W2912367139C89560881 @default.
- W2912367139 hasFunder F4320322729 @default.
- W2912367139 hasIssue "2" @default.
- W2912367139 hasLocation W29123671391 @default.
- W2912367139 hasLocation W29123671392 @default.
- W2912367139 hasOpenAccess W2912367139 @default.
- W2912367139 hasPrimaryLocation W29123671391 @default.
- W2912367139 hasRelatedWork W1569514087 @default.
- W2912367139 hasRelatedWork W1971262694 @default.
- W2912367139 hasRelatedWork W2034201747 @default.
- W2912367139 hasRelatedWork W2531895827 @default.
- W2912367139 hasRelatedWork W2765708136 @default.
- W2912367139 hasRelatedWork W2912367139 @default.
- W2912367139 hasRelatedWork W2972690579 @default.
- W2912367139 hasRelatedWork W3142616876 @default.
- W2912367139 hasRelatedWork W3194418772 @default.
- W2912367139 hasRelatedWork W4281755982 @default.
- W2912367139 hasVolume "78" @default.
- W2912367139 isParatext "false" @default.
- W2912367139 isRetracted "false" @default.
- W2912367139 magId "2912367139" @default.
- W2912367139 workType "article" @default.