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- W2912367592 abstract "The development of a skeletogenic condensation is perhaps the most critical yet considerably overlooked stage of skeletogenesis. Described in this comprehensive review are the mechanisms that facilitate skeletogenic condensation formation, growth, and maintenance to allow for overt differentiation into a skeletal element. This review discusses the current knowledge of gene regulation and characterization of skeletogenic condensations in the chicken, mouse, zebrafish, and other developmental models. We limited our scope to condensations that give rise to the bones and cartilages of the vertebrate skeleton, with a particular focus on craniofacial and limb bud regions. While many of the skeletogenic processes are similar among vertebrate lineages, differences are apparent in the site and timing of the initial epithelial–mesenchymal interactions as well as in whether the condensation has an osteogenic or chondrogenic fate, both within and among species. Further comparative studies are needed to clarify and broaden the existing knowledge of this intricate phenomenon." @default.
- W2912367592 created "2019-02-21" @default.
- W2912367592 creator A5039641843 @default.
- W2912367592 creator A5064249096 @default.
- W2912367592 creator A5083104416 @default.
- W2912367592 date "2019-02-01" @default.
- W2912367592 modified "2023-09-24" @default.
- W2912367592 title "The Forgotten Skeletogenic Condensations: A Comparison of Early Skeletal Development Amongst Vertebrates" @default.
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- W2912367592 doi "https://doi.org/10.3390/jdb7010004" @default.
- W2912367592 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6473759" @default.
- W2912367592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30717314" @default.
- W2912367592 hasPublicationYear "2019" @default.
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