FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912374763> ?p ?o ?g. }

• W2912374763 endingPage "450" @default.
• W2912374763 startingPage "444" @default.
• W2912374763 abstract "The balance between proliferation and apoptosis of vascular smooth muscle cells (VSMCs) plays a critical role in the initiation of atherosclerosis. LncRNA-MEG3 is involved in the pathophysiology of atherosclerosis through regulation of endothelial cell proliferation and migration. Its effect on the dysfunction of VSMCs and the corresponding mechanisms are actively researched. In this study, we observed that downregulated lncRNA-MEG3 expression was inversely correlated with the microRNA-26a level in coronary artery disease tissues. The overexpression of lncRNA-MEG3 could inhibit VSMCs proliferation while facilitating apoptosis. Moreover, alteration in the miR-26a/Smad1 axis could antagonize this effect. Bioinformatic analysis indicated that lncRNA-MEG3 could interact with miR-26a via complementary binding sites. The enforced expression of lncRNA-MEG3 could reduce the level of miR-26a in VSMCs, while the expression of Smad1 increases. Further, the direct binding between lncRNA-MEG3 and miR-26a was confirmed via dual-luciferase reporter assay, which indicated that lnc-MEG3 could sponge miR-26a as a competing endogenous RNA. In summary, we propose that lncRNA-MEG3 modulates the proliferation/apoptosis balance of VSMCs in atherosclerosis by regulating the miR-26a/Smad1 axis." @default.
• W2912374763 created "2019-02-21" @default.
• W2912374763 creator A5027628717 @default.
• W2912374763 creator A5029553658 @default.
• W2912374763 creator A5029740059 @default.
• W2912374763 creator A5029847599 @default.
• W2912374763 creator A5056338065 @default.
• W2912374763 date "2019-03-30" @default.
• W2912374763 modified "2023-10-11" @default.
• W2912374763 title "Modulation of the Proliferation/Apoptosis Balance of Vascular Smooth Muscle Cells in Atherosclerosis by lncRNA-MEG3 via Regulation of miR-26a/Smad1 Axis" @default.
• W2912374763 cites W1565801945 @default.
• W2912374763 cites W1951364332 @default.
• W2912374763 cites W2047493201 @default.
• W2912374763 cites W2071944562 @default.
• W2912374763 cites W2121772485 @default.
• W2912374763 cites W2122746315 @default.
• W2912374763 cites W2552206015 @default.
• W2912374763 cites W2553687558 @default.
• W2912374763 cites W2581950954 @default.
• W2912374763 cites W2592488370 @default.
• W2912374763 cites W2606188254 @default.
• W2912374763 cites W2615938559 @default.
• W2912374763 cites W2617831789 @default.
• W2912374763 cites W2729678748 @default.
• W2912374763 cites W2743174521 @default.
• W2912374763 cites W2759492059 @default.
• W2912374763 cites W2761624970 @default.
• W2912374763 cites W2783078009 @default.
• W2912374763 cites W2806944830 @default.
• W2912374763 doi "https://doi.org/10.1536/ihj.18-195" @default.
• W2912374763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30745534" @default.
• W2912374763 hasPublicationYear "2019" @default.
• W2912374763 type Work @default.
• W2912374763 sameAs 2912374763 @default.
• W2912374763 citedByCount "38" @default.
• W2912374763 countsByYear W29123747632019 @default.
• W2912374763 countsByYear W29123747632020 @default.
• W2912374763 countsByYear W29123747632021 @default.
• W2912374763 countsByYear W29123747632022 @default.
• W2912374763 countsByYear W29123747632023 @default.
• W2912374763 crossrefType "journal-article" @default.
• W2912374763 hasAuthorship W2912374763A5027628717 @default.
• W2912374763 hasAuthorship W2912374763A5029553658 @default.
• W2912374763 hasAuthorship W2912374763A5029740059 @default.
• W2912374763 hasAuthorship W2912374763A5029847599 @default.
• W2912374763 hasAuthorship W2912374763A5056338065 @default.
• W2912374763 hasBestOaLocation W29123747631 @default.
• W2912374763 hasConcept C104317684 @default.
• W2912374763 hasConcept C126322002 @default.
• W2912374763 hasConcept C127561419 @default.
• W2912374763 hasConcept C145059251 @default.
• W2912374763 hasConcept C190283241 @default.
• W2912374763 hasConcept C2779395532 @default.
• W2912374763 hasConcept C2781369401 @default.
• W2912374763 hasConcept C2992686903 @default.
• W2912374763 hasConcept C502942594 @default.
• W2912374763 hasConcept C55493867 @default.
• W2912374763 hasConcept C60365752 @default.
• W2912374763 hasConcept C62112901 @default.
• W2912374763 hasConcept C62203573 @default.
• W2912374763 hasConcept C62478195 @default.
• W2912374763 hasConcept C71924100 @default.
• W2912374763 hasConcept C86803240 @default.
• W2912374763 hasConcept C95444343 @default.
• W2912374763 hasConceptScore W2912374763C104317684 @default.
• W2912374763 hasConceptScore W2912374763C126322002 @default.
• W2912374763 hasConceptScore W2912374763C127561419 @default.
• W2912374763 hasConceptScore W2912374763C145059251 @default.
• W2912374763 hasConceptScore W2912374763C190283241 @default.
• W2912374763 hasConceptScore W2912374763C2779395532 @default.
• W2912374763 hasConceptScore W2912374763C2781369401 @default.
• W2912374763 hasConceptScore W2912374763C2992686903 @default.
• W2912374763 hasConceptScore W2912374763C502942594 @default.
• W2912374763 hasConceptScore W2912374763C55493867 @default.
• W2912374763 hasConceptScore W2912374763C60365752 @default.
• W2912374763 hasConceptScore W2912374763C62112901 @default.
• W2912374763 hasConceptScore W2912374763C62203573 @default.
• W2912374763 hasConceptScore W2912374763C62478195 @default.
• W2912374763 hasConceptScore W2912374763C71924100 @default.
• W2912374763 hasConceptScore W2912374763C86803240 @default.
• W2912374763 hasConceptScore W2912374763C95444343 @default.
• W2912374763 hasIssue "2" @default.
• W2912374763 hasLocation W29123747631 @default.
• W2912374763 hasLocation W29123747632 @default.
• W2912374763 hasOpenAccess W2912374763 @default.
• W2912374763 hasPrimaryLocation W29123747631 @default.
• W2912374763 hasRelatedWork W2605001769 @default.
• W2912374763 hasRelatedWork W2774992434 @default.
• W2912374763 hasRelatedWork W2891165745 @default.
• W2912374763 hasRelatedWork W2896541536 @default.
• W2912374763 hasRelatedWork W2981288050 @default.
• W2912374763 hasRelatedWork W2981291069 @default.
• W2912374763 hasRelatedWork W3095452002 @default.
• W2912374763 hasRelatedWork W4225093829 @default.
• W2912374763 hasRelatedWork W4225702286 @default.
• W2912374763 hasRelatedWork W4245617172 @default.
• W2912374763 hasVolume "60" @default.
• W2912374763 isParatext "false" @default.

• next