FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912377866> ?p ?o ?g. }

• W2912377866 endingPage "110" @default.
• W2912377866 startingPage "105" @default.
• W2912377866 abstract "N-glycans influence the activity of antibody drugs such as antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). Thus, glycan profiling is considered a critical quality attribute (CQA) and requires routine and comprehensive monitoring. In this report, we validate the new glycan profiling method called Rapi-Fluor method, which reduced the sample preparation time and increased the FLR and MS intensities compared with conventional 2-AB method. Optimized glycan release, labeling, hydrophilic interaction liquid chromatography (HILIC) enrichment, and HILIC separation resulted in low variation and short preparation time. The method evaluated for human IgG standard varied from 100 µg/mL to 4000 µg/mL in 25 µL of water. The determination of coefficient (r2 > 0.9992), recovery (88.992% ~ 111.198%), limit of detection (LOD < 193.274 µg/mL), limit of quantification (LOQ < 585.679 µg/mL), and precision (Intra-day < 2.317%RSD and Inter-day < 4.287%RSD) were evaluated with four major glycans from antibody drugs. In addition, the method was used for glycan profiling of five different commercial antibodies. The method yielded precise results for IgG glycan analysis and demonstrated effective glycan profiling of commercial antibody drugs." @default.
• W2912377866 created "2019-02-21" @default.
• W2912377866 creator A5006664037 @default.
• W2912377866 creator A5018906344 @default.
• W2912377866 creator A5021022981 @default.
• W2912377866 creator A5023642117 @default.
• W2912377866 creator A5032568552 @default.
• W2912377866 creator A5060220147 @default.
• W2912377866 creator A5086055539 @default.
• W2912377866 date "2019-06-01" @default.
• W2912377866 modified "2023-09-25" @default.
• W2912377866 title "Validation of Rapi-Fluor method for glycan profiling and application to commercial antibody drugs" @default.
• W2912377866 cites W1503491996 @default.
• W2912377866 cites W1971014721 @default.
• W2912377866 cites W1972913960 @default.
• W2912377866 cites W1978124145 @default.
• W2912377866 cites W1985476025 @default.
• W2912377866 cites W1986197388 @default.
• W2912377866 cites W2023749561 @default.
• W2912377866 cites W2029897291 @default.
• W2912377866 cites W2032298687 @default.
• W2912377866 cites W2035118667 @default.
• W2912377866 cites W2037656934 @default.
• W2912377866 cites W2043272559 @default.
• W2912377866 cites W2054454917 @default.
• W2912377866 cites W2063264794 @default.
• W2912377866 cites W2073948759 @default.
• W2912377866 cites W2074589683 @default.
• W2912377866 cites W2075901113 @default.
• W2912377866 cites W2082214675 @default.
• W2912377866 cites W2087336334 @default.
• W2912377866 cites W2091229935 @default.
• W2912377866 cites W2141073877 @default.
• W2912377866 cites W2145804903 @default.
• W2912377866 cites W2326601291 @default.
• W2912377866 cites W2330451514 @default.
• W2912377866 cites W2602681748 @default.
• W2912377866 cites W2763231564 @default.
• W2912377866 cites W2763901610 @default.
• W2912377866 doi "https://doi.org/10.1016/j.talanta.2019.01.093" @default.
• W2912377866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30876537" @default.
• W2912377866 hasPublicationYear "2019" @default.
• W2912377866 type Work @default.
• W2912377866 sameAs 2912377866 @default.
• W2912377866 citedByCount "13" @default.
• W2912377866 countsByYear W29123778662019 @default.
• W2912377866 countsByYear W29123778662020 @default.
• W2912377866 countsByYear W29123778662021 @default.
• W2912377866 countsByYear W29123778662022 @default.
• W2912377866 countsByYear W29123778662023 @default.
• W2912377866 crossrefType "journal-article" @default.
• W2912377866 hasAuthorship W2912377866A5006664037 @default.
• W2912377866 hasAuthorship W2912377866A5018906344 @default.
• W2912377866 hasAuthorship W2912377866A5021022981 @default.
• W2912377866 hasAuthorship W2912377866A5023642117 @default.
• W2912377866 hasAuthorship W2912377866A5032568552 @default.
• W2912377866 hasAuthorship W2912377866A5060220147 @default.
• W2912377866 hasAuthorship W2912377866A5086055539 @default.
• W2912377866 hasConcept C108625454 @default.
• W2912377866 hasConcept C109316439 @default.
• W2912377866 hasConcept C116817701 @default.
• W2912377866 hasConcept C119128265 @default.
• W2912377866 hasConcept C159654299 @default.
• W2912377866 hasConcept C179998833 @default.
• W2912377866 hasConcept C185592680 @default.
• W2912377866 hasConcept C202751555 @default.
• W2912377866 hasConcept C203014093 @default.
• W2912377866 hasConcept C206212055 @default.
• W2912377866 hasConcept C40677261 @default.
• W2912377866 hasConcept C43617362 @default.
• W2912377866 hasConcept C55493867 @default.
• W2912377866 hasConcept C86803240 @default.
• W2912377866 hasConcept C89838059 @default.
• W2912377866 hasConceptScore W2912377866C108625454 @default.
• W2912377866 hasConceptScore W2912377866C109316439 @default.
• W2912377866 hasConceptScore W2912377866C116817701 @default.
• W2912377866 hasConceptScore W2912377866C119128265 @default.
• W2912377866 hasConceptScore W2912377866C159654299 @default.
• W2912377866 hasConceptScore W2912377866C179998833 @default.
• W2912377866 hasConceptScore W2912377866C185592680 @default.
• W2912377866 hasConceptScore W2912377866C202751555 @default.
• W2912377866 hasConceptScore W2912377866C203014093 @default.
• W2912377866 hasConceptScore W2912377866C206212055 @default.
• W2912377866 hasConceptScore W2912377866C40677261 @default.
• W2912377866 hasConceptScore W2912377866C43617362 @default.
• W2912377866 hasConceptScore W2912377866C55493867 @default.
• W2912377866 hasConceptScore W2912377866C86803240 @default.
• W2912377866 hasConceptScore W2912377866C89838059 @default.
• W2912377866 hasFunder F4320322120 @default.
• W2912377866 hasLocation W29123778661 @default.
• W2912377866 hasLocation W29123778662 @default.
• W2912377866 hasOpenAccess W2912377866 @default.
• W2912377866 hasPrimaryLocation W29123778661 @default.
• W2912377866 hasRelatedWork W1575563626 @default.
• W2912377866 hasRelatedWork W1967470546 @default.
• W2912377866 hasRelatedWork W2023831371 @default.
• W2912377866 hasRelatedWork W2078069482 @default.
• W2912377866 hasRelatedWork W2082247235 @default.

• next