Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912378379> ?p ?o ?g. }
- W2912378379 endingPage "1390" @default.
- W2912378379 startingPage "1379" @default.
- W2912378379 abstract "The incidence of urinary stone disease (USD) has increased four-fold in 50 years. Oxalate, which is degraded exclusively by gut bacteria, is an important constituent in 80% of urinary stones. We quantified the effects of antibiotics and a high fat/high sugar (HFHS) diet on the microbial metabolism of oxalate in the gut. High and low oxalate-degrading mouse models were developed by administering fecal transplants from either the wild mammalian rodent Neotoma albigula or Swiss-Webster mice to Swiss-Webster mice, which produces a microbiota with or without the bacteria necessary for persistent oxalate metabolism, respectively. Antibiotics led to an acute loss of both transplant bacteria and associated oxalate metabolism. Transplant bacteria exhibited some recovery over time but oxalate metabolism did not. In contrast, a HFHS diet led to an acute loss of function coupled with a gradual loss of transplant bacteria, indicative of a shift in overall microbial metabolism. Thus, the effects of oral antibiotics on the microbiome form and function were greater than the effects of diet. Results indicate that both antibiotics and diet strongly influence microbial oxalate metabolism." @default.
- W2912378379 created "2019-02-21" @default.
- W2912378379 creator A5020056284 @default.
- W2912378379 creator A5031950979 @default.
- W2912378379 creator A5045144560 @default.
- W2912378379 creator A5078044251 @default.
- W2912378379 date "2019-01-30" @default.
- W2912378379 modified "2023-10-18" @default.
- W2912378379 title "Loss of function dysbiosis associated with antibiotics and high fat, high sugar diet" @default.
- W2912378379 cites W1207276 @default.
- W2912378379 cites W1485645868 @default.
- W2912378379 cites W1487811474 @default.
- W2912378379 cites W1506141487 @default.
- W2912378379 cites W1570492102 @default.
- W2912378379 cites W1592527426 @default.
- W2912378379 cites W1707001945 @default.
- W2912378379 cites W1947544625 @default.
- W2912378379 cites W1967821667 @default.
- W2912378379 cites W1971197629 @default.
- W2912378379 cites W1979573684 @default.
- W2912378379 cites W1981729222 @default.
- W2912378379 cites W1988821718 @default.
- W2912378379 cites W1995545250 @default.
- W2912378379 cites W2000450805 @default.
- W2912378379 cites W2000920418 @default.
- W2912378379 cites W2010050543 @default.
- W2912378379 cites W2010149962 @default.
- W2912378379 cites W2012490955 @default.
- W2912378379 cites W2018054151 @default.
- W2912378379 cites W202448693 @default.
- W2912378379 cites W2028476708 @default.
- W2912378379 cites W2030571305 @default.
- W2912378379 cites W2031978566 @default.
- W2912378379 cites W2038167843 @default.
- W2912378379 cites W2038217946 @default.
- W2912378379 cites W2038420926 @default.
- W2912378379 cites W2041136224 @default.
- W2912378379 cites W2043442946 @default.
- W2912378379 cites W2047059509 @default.
- W2912378379 cites W2050346837 @default.
- W2912378379 cites W2052179757 @default.
- W2912378379 cites W2052554412 @default.
- W2912378379 cites W2056908338 @default.
- W2912378379 cites W2058086874 @default.
- W2912378379 cites W2071841602 @default.
- W2912378379 cites W2072970694 @default.
- W2912378379 cites W2074263634 @default.
- W2912378379 cites W2083501377 @default.
- W2912378379 cites W2088170171 @default.
- W2912378379 cites W2090925778 @default.
- W2912378379 cites W2091180702 @default.
- W2912378379 cites W2093715975 @default.
- W2912378379 cites W2097776160 @default.
- W2912378379 cites W2097875133 @default.
- W2912378379 cites W2101752541 @default.
- W2912378379 cites W2102914004 @default.
- W2912378379 cites W2103015797 @default.
- W2912378379 cites W2104843155 @default.
- W2912378379 cites W2105973208 @default.
- W2912378379 cites W2108680415 @default.
- W2912378379 cites W2109392327 @default.
- W2912378379 cites W2110235509 @default.
- W2912378379 cites W2112874908 @default.
- W2912378379 cites W2113977541 @default.
- W2912378379 cites W2124351063 @default.
- W2912378379 cites W2129917444 @default.
- W2912378379 cites W2136879569 @default.
- W2912378379 cites W2139190685 @default.
- W2912378379 cites W2139607253 @default.
- W2912378379 cites W2140598936 @default.
- W2912378379 cites W2140624763 @default.
- W2912378379 cites W2141172032 @default.
- W2912378379 cites W2144076743 @default.
- W2912378379 cites W2144568881 @default.
- W2912378379 cites W2145749857 @default.
- W2912378379 cites W2146401071 @default.
- W2912378379 cites W2147790901 @default.
- W2912378379 cites W2148493668 @default.
- W2912378379 cites W2149376991 @default.
- W2912378379 cites W2149573313 @default.
- W2912378379 cites W2149711482 @default.
- W2912378379 cites W2149756110 @default.
- W2912378379 cites W2151901229 @default.
- W2912378379 cites W2152616728 @default.
- W2912378379 cites W2153075279 @default.
- W2912378379 cites W2154026962 @default.
- W2912378379 cites W2154886088 @default.
- W2912378379 cites W2155594310 @default.
- W2912378379 cites W2156145269 @default.
- W2912378379 cites W2156403523 @default.
- W2912378379 cites W2158626993 @default.
- W2912378379 cites W2159675211 @default.
- W2912378379 cites W2165065263 @default.
- W2912378379 cites W2166171121 @default.
- W2912378379 cites W2168162793 @default.
- W2912378379 cites W2169882854 @default.
- W2912378379 cites W2171942415 @default.
- W2912378379 cites W2175370616 @default.