Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912378783> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2912378783 endingPage "S22" @default.
- W2912378783 startingPage "S22" @default.
- W2912378783 abstract "Pubertal immune challenge can permanently alter hippocampus-dependent memory processes in a sex-specific manner. Although gonadal hormones can influence various cognitive processes, their role in regulating the cognitive sequelae to pubertal immune challenge has not been thoroughly assessed. We examined whether a pubertal immune challenge could affect hippocampus-dependent memory functions in adulthood and whether these effects are regulated by gonadal steroid hormones. We hypothesized that exposure to an immune challenge during puberty would induce sex-specific deficits in the behavioral and cellular correlates of hippocampus-dependent memory during adulthood. At six weeks of age, during the stress-vulnerable pubertal period, male and female CD-1 mice were injected with either saline or the bacterial endotoxin lipopolysaccharide (LPS). Three weeks later, mice underwent either gonadectomy or sham-surgery. At ten weeks of age (i.e., in adulthood), mice began behavioral testing in an open field, Barnes maze, and Morris water maze. Brain tissue was collected at 17 weeks of age and stained for doublecortin and Ki67 to examine migrating neuronal progenitor cells and cellular proliferation in the neurogenic subgranular zone (SGZ) and the cornus ammonis (CA)1 and CA3 regions of the hippocampus. Pubertal LPS treatment impaired learning during adulthood in both sexes and increased cellular proliferation in the CA1 region in castrated males only. Although adult sex hormones did not reliably modulate these changes, gonadectomy impaired learning during the Morris water maze in both sexes. Learning deficits were more prominent during the Barnes maze, which suggests a stress-dependent expression of LPS-induced cognitive deficits. Neurogenesis in the SGZ and cellular proliferation in the CA3 were not affected by pubertal LPS treatment or gonadectomy. These novel findings emphasize the sensitivity of developing cognitive processes during puberty to immune challenges and suggest a possible mechanism for learning-based difficulties in adulthood." @default.
- W2912378783 created "2019-02-21" @default.
- W2912378783 creator A5003900578 @default.
- W2912378783 creator A5008884822 @default.
- W2912378783 creator A5028816823 @default.
- W2912378783 creator A5036933917 @default.
- W2912378783 creator A5043612650 @default.
- W2912378783 creator A5047759783 @default.
- W2912378783 creator A5077706003 @default.
- W2912378783 creator A5082726895 @default.
- W2912378783 date "2019-02-01" @default.
- W2912378783 modified "2023-09-26" @default.
- W2912378783 title "Inflammatory biomarkers in individuals exposed to early life stress: a systematic review and meta-analysis" @default.
- W2912378783 doi "https://doi.org/10.1016/j.psyneuen.2018.12.086" @default.
- W2912378783 hasPublicationYear "2019" @default.
- W2912378783 type Work @default.
- W2912378783 sameAs 2912378783 @default.
- W2912378783 citedByCount "0" @default.
- W2912378783 crossrefType "journal-article" @default.
- W2912378783 hasAuthorship W2912378783A5003900578 @default.
- W2912378783 hasAuthorship W2912378783A5008884822 @default.
- W2912378783 hasAuthorship W2912378783A5028816823 @default.
- W2912378783 hasAuthorship W2912378783A5036933917 @default.
- W2912378783 hasAuthorship W2912378783A5043612650 @default.
- W2912378783 hasAuthorship W2912378783A5047759783 @default.
- W2912378783 hasAuthorship W2912378783A5077706003 @default.
- W2912378783 hasAuthorship W2912378783A5082726895 @default.
- W2912378783 hasConcept C118552586 @default.
- W2912378783 hasConcept C12515866 @default.
- W2912378783 hasConcept C126322002 @default.
- W2912378783 hasConcept C134018914 @default.
- W2912378783 hasConcept C15744967 @default.
- W2912378783 hasConcept C169760540 @default.
- W2912378783 hasConcept C173586616 @default.
- W2912378783 hasConcept C201750760 @default.
- W2912378783 hasConcept C2775858765 @default.
- W2912378783 hasConcept C2776464000 @default.
- W2912378783 hasConcept C2777542384 @default.
- W2912378783 hasConcept C2779085643 @default.
- W2912378783 hasConcept C2781161787 @default.
- W2912378783 hasConcept C2781176699 @default.
- W2912378783 hasConcept C2781461022 @default.
- W2912378783 hasConcept C28328180 @default.
- W2912378783 hasConcept C2985665543 @default.
- W2912378783 hasConcept C44752575 @default.
- W2912378783 hasConcept C4746552 @default.
- W2912378783 hasConcept C54355233 @default.
- W2912378783 hasConcept C558461103 @default.
- W2912378783 hasConcept C71924100 @default.
- W2912378783 hasConcept C86803240 @default.
- W2912378783 hasConceptScore W2912378783C118552586 @default.
- W2912378783 hasConceptScore W2912378783C12515866 @default.
- W2912378783 hasConceptScore W2912378783C126322002 @default.
- W2912378783 hasConceptScore W2912378783C134018914 @default.
- W2912378783 hasConceptScore W2912378783C15744967 @default.
- W2912378783 hasConceptScore W2912378783C169760540 @default.
- W2912378783 hasConceptScore W2912378783C173586616 @default.
- W2912378783 hasConceptScore W2912378783C201750760 @default.
- W2912378783 hasConceptScore W2912378783C2775858765 @default.
- W2912378783 hasConceptScore W2912378783C2776464000 @default.
- W2912378783 hasConceptScore W2912378783C2777542384 @default.
- W2912378783 hasConceptScore W2912378783C2779085643 @default.
- W2912378783 hasConceptScore W2912378783C2781161787 @default.
- W2912378783 hasConceptScore W2912378783C2781176699 @default.
- W2912378783 hasConceptScore W2912378783C2781461022 @default.
- W2912378783 hasConceptScore W2912378783C28328180 @default.
- W2912378783 hasConceptScore W2912378783C2985665543 @default.
- W2912378783 hasConceptScore W2912378783C44752575 @default.
- W2912378783 hasConceptScore W2912378783C4746552 @default.
- W2912378783 hasConceptScore W2912378783C54355233 @default.
- W2912378783 hasConceptScore W2912378783C558461103 @default.
- W2912378783 hasConceptScore W2912378783C71924100 @default.
- W2912378783 hasConceptScore W2912378783C86803240 @default.
- W2912378783 hasLocation W29123787831 @default.
- W2912378783 hasOpenAccess W2912378783 @default.
- W2912378783 hasPrimaryLocation W29123787831 @default.
- W2912378783 hasRelatedWork W1994193742 @default.
- W2912378783 hasRelatedWork W1996840208 @default.
- W2912378783 hasRelatedWork W2091952969 @default.
- W2912378783 hasRelatedWork W2106478988 @default.
- W2912378783 hasRelatedWork W2114305482 @default.
- W2912378783 hasRelatedWork W2373623307 @default.
- W2912378783 hasRelatedWork W2502680778 @default.
- W2912378783 hasRelatedWork W2904825052 @default.
- W2912378783 hasRelatedWork W2981288334 @default.
- W2912378783 hasRelatedWork W4324071209 @default.
- W2912378783 hasVolume "100" @default.
- W2912378783 isParatext "false" @default.
- W2912378783 isRetracted "false" @default.
- W2912378783 magId "2912378783" @default.
- W2912378783 workType "article" @default.