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- W2912382051 abstract "Local allergic rhinitis (LAR) is characterized by local allergic inflammation in nasal cavity and negative skin prick test (SPT) and serum specific Ig E (sIgE). The prevalence of LAR is varying from different country, study group and age ranges. This study was to determine the prevalence and characteristics of LAR to Dermatophagoides pteronyssinus (Der p) in Thai children with chronic rhinitis. Children 5-18 years with chronic rhinitis were recruited. SPTs with the common inhalant aeroallergens and Phadiatop® were conducted. Nasal allergen provocation test (NAPT) with Der p, at 15-minutes interval and peak inspiratory flow (PNIF) were performed in all patients. One hundred children with chronic rhinitis were enrolled with the mean age of 9.7 ±3 year, 58 % were male. Allergic rhinitis (AR) was diagnosed in 61 patients (positive SPT or Phadiatop®). Among 39 children who had negative result of SPT and negative for Phadiatop®, 9 children had positive responses to NAPT with Der p. As a result, the prevalence of LAR was 9% in children with chronic rhinitis, and 23% in children with negative SPT and Phadiatop®. There was a significant difference in age between AR and NAR groups 10.4 ±3.1 vs 8.5 ±2.7 year, P=0.02. Percentage of playing with dolls was significantly higher in LAR than NAR (88.9% vs 37.9%, P=0.019) in subgroup analysis. LAR is not uncommon in children with chronic rhinitis and must be considered in patients with typical AR symptoms but neither negative SPT nor sIgE. NAPT should be performed for diagnosis LAR." @default.
- W2912382051 created "2019-02-21" @default.
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- W2912382051 date "2019-02-01" @default.
- W2912382051 modified "2023-10-18" @default.
- W2912382051 title "Local Allergic Rhinitis with House Dust Mite Allergy in Thai Children with Chronic Rhinitis" @default.
- W2912382051 doi "https://doi.org/10.1016/j.jaci.2018.12.541" @default.
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