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- W2912383101 endingPage "10" @default.
- W2912383101 startingPage "1" @default.
- W2912383101 abstract "There are several DNA helicases involved in seemingly overlapping aspects of homologous and homoeologous recombination. Mutations of many of these helicases are directly implicated in genetic diseases including cancer, rapid aging, and infertility. MCM8/9 are recent additions to the catalog of helicases involved in recombination, and so far, the evidence is sparse, making assignment of function difficult. Mutations in MCM8/9 correlate principally with primary ovarian failure/insufficiency (POF/POI) and infertility indicating a meiotic defect. However, they also act when replication forks collapse/break shuttling products into mitotic recombination and several mutations are found in various somatic cancers. This review puts MCM8/9 in context with other replication and recombination helicases to narrow down its genomic maintenance role. We discuss the known structure/function relationship, the mutational spectrum, and dissect the available cellular and organismal data to better define its role in recombination." @default.
- W2912383101 created "2019-02-21" @default.
- W2912383101 creator A5033876035 @default.
- W2912383101 creator A5088662521 @default.
- W2912383101 date "2019-04-01" @default.
- W2912383101 modified "2023-09-29" @default.
- W2912383101 title "The MCM8/9 complex: A recent recruit to the roster of helicases involved in genome maintenance" @default.
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