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- W2912385585 abstract "Eukaryotic mRNAs frequently contain upstream open reading frames (uORFs), encoding small peptides that may control translation of the main ORF (mORF). Here, we report the characterization of a distinct bicistronic transcript in Arabidopsis. We analysed loss-of-function phenotypes of the inorganic polyphosphatase TRIPHOSPHATE TUNNEL METALLOENZYME 3 (AtTTM3), and found that catalytically inactive versions of the enzyme could fully complement embryo and growth-related phenotypes. We could rationalize these puzzling findings by characterizing a uORF in the AtTTM3 locus encoding CELL DIVISION CYCLE PROTEIN 26 (CDC26), an orthologue of the cell cycle regulator. We demonstrate that AtCDC26 is part of the plant anaphase promoting complex/cyclosome (APC/C), regulates accumulation of APC/C target proteins and controls cell division, growth and embryo development. AtCDC26 and AtTTM3 are translated from a single transcript conserved across the plant lineage. While there is no apparent biochemical connection between the two gene products, AtTTM3 coordinates AtCDC26 translation by recruiting the transcript into polysomes. Our work highlights that uORFs may encode functional proteins in plant genomes. Eukaryotic mRNAs often contain upstream open reading frames for small peptides. However, this study reports a truly bicistronic transcript in Arabidopsis, which encodes both CELL DIVISION CYCLE 26, a cell cycle regulator, and TRIPHOSPHATE TUNNEL METALLOENZYME 3, an inorganic polyphosphatase." @default.
- W2912385585 created "2019-02-21" @default.
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- W2912385585 date "2019-02-08" @default.
- W2912385585 modified "2023-10-17" @default.
- W2912385585 title "Concerted expression of a cell cycle regulator and a metabolic enzyme from a bicistronic transcript in plants" @default.
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- W2912385585 doi "https://doi.org/10.1038/s41477-019-0358-3" @default.
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