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• W2912385593 abstract "Indocyanine green-based fluorescence imaging techniques are very powerful in clinical applications, but the imaging is restricted to the signal from the near-surface region of tissue. Here, we focus on the method to discriminate the fluorescence signal from the background using a time-domain gating technique. The contrast of the fluorescence image from a fluorescence object at more than 1 cm depth in a meat phantom could be enhanced about 4-5 times relative to the continuous wave method if the time-gate range was properly selected. Further, a Monte Carlo simulation with a simple background model indicates that a shorter source and detector distance is more effective to improve the contrast. The simple time-gating method will enable a highly sensitive fluorescence detection in thick tissue." @default.
• W2912385593 created "2019-02-21" @default.
• W2912385593 creator A5087648506 @default.
• W2912385593 date "2019-02-12" @default.
• W2912385593 modified "2023-09-27" @default.
• W2912385593 title "Contrast improvement in indocyanine green fluorescence sensing in thick tissue using a time-gating method" @default.
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• W2912385593 doi "https://doi.org/10.1364/boe.10.001234" @default.
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