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• W2912386434 abstract "Protease inhibitors (PIs) select more mutations than any other class of antiretroviral drugs (ARV). The objective of our study was to determine minor and major mutations in HIV-1 protease that may decrease the efficacy of PIs in children. The determination of mutations and their interpretations were performed using ANRS techniques and algorithms (www.hivfrenchresistance.org). Sequence analysis identified 13% of children resistant to PIs. Frequent minor mutations were M36I and K20I (100% respectively), H69K (88%), L89M and I54V (75% respectively) and G16E (50%). The major mutations were V82A (75%), M46I (63%), L90M (38%) and L76V (13%). Resistance was noted to Indinavir (IDV) and Fosamprenavir/Ritonavir (FPV/r) (75% respectively), Nelfinavir (NFV) and Saquinavir/Ritonavir (SQV/r) (50% respectively), Atazanavir/Ritonavir (ATV/r) (38%) and Lopinavir/Ritonavir (LPV/r) (25%). This study identified mutations associated with PIs resistance in children. The minor mutations frequently encountered whose association with other mutations cause resistance to LPV/r and ATV/r respectively were I54V and G16E. The major mutation responsible for resistance to LPV/r was L76V. The combination of minor and major mutations frequently associated with PIs ineffectiveness was the combination of 4 mutations, I54V, V82A, L90M and M46I for LPV/r and 3 mutations, G16E, L90M and M46I for ATV/r. No resistance to DRV/r was observed, it could be a surrogate molecule." @default.
• W2912386434 created "2019-02-21" @default.
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• W2912386434 date "2018-01-01" @default.
• W2912386434 modified "2023-09-24" @default.
• W2912386434 title "Protease Inhibitor Resistance Mutation Profile in Children on Antiretroviral Therapy for at Least Six Months in Abidjan (Côte d’Ivoire)" @default.
• W2912386434 hasPublicationYear "2018" @default.
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