Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912386902> ?p ?o ?g. }
- W2912386902 endingPage "330" @default.
- W2912386902 startingPage "319" @default.
- W2912386902 abstract "A microbial catalysis is an effective tool for steroid structural modifications allowing generating the compounds which may be difficult to obtain by conventional synthetic methods. Selected fungal strains of Ascomycota and Zygomycota divisions (totally, 75) representing different phyla were screened for their activity toward 3β-hydroxypregn-5-ene-20-one (pregnenolone) focusing on the production of 11α-hydroxyprogesterone. Along with the ability to catalyze 7α-, 7β- and 11α-hydroxylation which was revealed for some representatives of Pleosporaceae, Trichocomaceae, Hypocreaceae, Clavicipitaceae, Microascaceae, Cunninghamellaceae, Mucoraceae and Phycomycetaceae families, micromycete strains belonging to Acremonium, Aspergillus, Curvularia, Rhizopus, and Scopulariopsis genera were selected capable of modifying 3β-ol-5-ene- to 3-keto-4-ene moiety, - this reaction being rather uncommon for fungi. The ability to catalyze double hydroxylation of pregnenolone at positions 7β and 11α by some tested micromycetes was revealed for the first time. Sustainable and high-efficient single-stage production of 11α-hydroxyprogesterone (up to 70%) from pregnenolone which was hitherto unreported was reached with the strain of Aspergillus niger VKM F-212 under the optimized conditions. The results demonstrate a highly diverse biocatalytic potential of fungal strains towards pregnenolone, reveal the existence of novel active biocatalysts that can be exploited for the synthesis of high-value hydroxysteroids and expand knowledge on structural modifications of steroid molecules in lower eukaryotes." @default.
- W2912386902 created "2019-02-21" @default.
- W2912386902 creator A5003365036 @default.
- W2912386902 creator A5016082852 @default.
- W2912386902 creator A5020808436 @default.
- W2912386902 creator A5079778993 @default.
- W2912386902 date "2019-01-26" @default.
- W2912386902 modified "2023-09-30" @default.
- W2912386902 title "Biocatalytic modifications of pregnenolone by selected filamentous fungi" @default.
- W2912386902 cites W1593587637 @default.
- W2912386902 cites W1905932321 @default.
- W2912386902 cites W1936401496 @default.
- W2912386902 cites W1976779226 @default.
- W2912386902 cites W1977461646 @default.
- W2912386902 cites W1982983101 @default.
- W2912386902 cites W1986416108 @default.
- W2912386902 cites W1992962199 @default.
- W2912386902 cites W1999428611 @default.
- W2912386902 cites W2001558926 @default.
- W2912386902 cites W2001877724 @default.
- W2912386902 cites W2002162945 @default.
- W2912386902 cites W2003574665 @default.
- W2912386902 cites W2008538903 @default.
- W2912386902 cites W2018701710 @default.
- W2912386902 cites W2025883867 @default.
- W2912386902 cites W2027090620 @default.
- W2912386902 cites W2052883593 @default.
- W2912386902 cites W2053658952 @default.
- W2912386902 cites W2058087708 @default.
- W2912386902 cites W2062076128 @default.
- W2912386902 cites W2065413990 @default.
- W2912386902 cites W2067038728 @default.
- W2912386902 cites W2073793653 @default.
- W2912386902 cites W2075184086 @default.
- W2912386902 cites W2080551977 @default.
- W2912386902 cites W2085243419 @default.
- W2912386902 cites W2088473383 @default.
- W2912386902 cites W2091502401 @default.
- W2912386902 cites W2149025230 @default.
- W2912386902 cites W2219382286 @default.
- W2912386902 cites W2311276428 @default.
- W2912386902 cites W2336561311 @default.
- W2912386902 cites W2506970187 @default.
- W2912386902 cites W2644412187 @default.
- W2912386902 cites W2734571045 @default.
- W2912386902 cites W2753056095 @default.
- W2912386902 cites W2789765819 @default.
- W2912386902 cites W4252429874 @default.
- W2912386902 doi "https://doi.org/10.1080/10242422.2018.1549237" @default.
- W2912386902 hasPublicationYear "2019" @default.
- W2912386902 type Work @default.
- W2912386902 sameAs 2912386902 @default.
- W2912386902 citedByCount "9" @default.
- W2912386902 countsByYear W29123869022019 @default.
- W2912386902 countsByYear W29123869022020 @default.
- W2912386902 countsByYear W29123869022021 @default.
- W2912386902 countsByYear W29123869022022 @default.
- W2912386902 crossrefType "journal-article" @default.
- W2912386902 hasAuthorship W2912386902A5003365036 @default.
- W2912386902 hasAuthorship W2912386902A5016082852 @default.
- W2912386902 hasAuthorship W2912386902A5020808436 @default.
- W2912386902 hasAuthorship W2912386902A5079778993 @default.
- W2912386902 hasConcept C104317684 @default.
- W2912386902 hasConcept C143065580 @default.
- W2912386902 hasConcept C181199279 @default.
- W2912386902 hasConcept C185592680 @default.
- W2912386902 hasConcept C2776923806 @default.
- W2912386902 hasConcept C2779344128 @default.
- W2912386902 hasConcept C2780193516 @default.
- W2912386902 hasConcept C2780902042 @default.
- W2912386902 hasConcept C2781109383 @default.
- W2912386902 hasConcept C2781212518 @default.
- W2912386902 hasConcept C55493867 @default.
- W2912386902 hasConcept C59822182 @default.
- W2912386902 hasConcept C71240020 @default.
- W2912386902 hasConcept C71315377 @default.
- W2912386902 hasConcept C86803240 @default.
- W2912386902 hasConceptScore W2912386902C104317684 @default.
- W2912386902 hasConceptScore W2912386902C143065580 @default.
- W2912386902 hasConceptScore W2912386902C181199279 @default.
- W2912386902 hasConceptScore W2912386902C185592680 @default.
- W2912386902 hasConceptScore W2912386902C2776923806 @default.
- W2912386902 hasConceptScore W2912386902C2779344128 @default.
- W2912386902 hasConceptScore W2912386902C2780193516 @default.
- W2912386902 hasConceptScore W2912386902C2780902042 @default.
- W2912386902 hasConceptScore W2912386902C2781109383 @default.
- W2912386902 hasConceptScore W2912386902C2781212518 @default.
- W2912386902 hasConceptScore W2912386902C55493867 @default.
- W2912386902 hasConceptScore W2912386902C59822182 @default.
- W2912386902 hasConceptScore W2912386902C71240020 @default.
- W2912386902 hasConceptScore W2912386902C71315377 @default.
- W2912386902 hasConceptScore W2912386902C86803240 @default.
- W2912386902 hasFunder F4320324099 @default.
- W2912386902 hasIssue "5" @default.
- W2912386902 hasLocation W29123869021 @default.
- W2912386902 hasOpenAccess W2912386902 @default.
- W2912386902 hasPrimaryLocation W29123869021 @default.
- W2912386902 hasRelatedWork W1548742343 @default.