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• W2912387040 abstract "ABSTRACT Aim Bioimpedance spectroscopy (BIS) allows volume status to be assessed objectively. This study evaluated the effect of BIS‐guided fluid management on residual kidney function (RKF), volume status, and cardiovascular events in peritoneal dialysis (PD) patients. Methods A multicenter, prospective, randomized, controlled trial was conducted over 12 months in 2013–2017. Non‐anuric PD patients (urine volume ≥ 500 mL/day) were randomized to clinical method‐guided management ( n = 98) or BIS‐guided management ( n = 103). The volume in the BIS group was controlled with BIS, with the aim of achieving the target overhydration (OH) goal of −2.0 to +2.0 L. The volume in the control group was controlled by clinical assessment alone. The groups were compared in terms of change in RKF and volume status at 12 months relative to baseline and in terms of cardiovascular event rates during a median follow‐up period of 36 months. Results Compared with the controls, the BIS group did not show a significant improvement in change in OH, after adjustments were made for covariates ( P = 0.191). The two groups did not differ in terms of delta OH, renal creatinine and urea clearance, and 24 h urine volume. The control and BIS groups also did not differ significantly in terms of change in peritoneal ultrafiltration volume, blood pressure, body weight and echocardiographic variables or in cardiovascular event rates (10.2% vs 11.3%; P = 0.953). Conclusion Bioimpedance spectroscopy‐guided fluid management did not show an additional benefit to achieve euvolemia, and did not affect the decline in RKF in non‐anuric PD patients." @default.
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• W2912387040 date "2019-04-25" @default.
• W2912387040 modified "2023-09-27" @default.
• W2912387040 title "Bioimpedance spectroscopy‐guided fluid management in peritoneal dialysis patients with residual kidney function: A randomized controlled trial" @default.
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• W2912387040 doi "https://doi.org/10.1111/nep.13571" @default.
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