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- W2912387720 abstract "Significance Digital assays have enormous untapped potential for diagnostics, environmental surveillance, and biosafety monitoring, but are currently confined to laboratory settings due to the instrumentation necessary to generate, control, and measure millions of droplets. We instead use a mobile phone-based imaging technique that is <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML overflow=scroll> <mml:mo>></mml:mo> </mml:math> 100× faster than conventional microfluidic droplet detection, does not require expensive optics, is invariant to flow rate, and can simultaneously measure multiple fluorescent dyes in droplets. By using this time domain modulation with cloud computing, we overcome the low frame rate of digital imaging, and achieve throughputs as high as 1 million droplets per second. We integrate on-chip delay lines and a microbead processing unit, resulting in a robust device, suitable for low-cost implementation, with ultrasensitive measurement capabilities." @default.
- W2912387720 created "2019-02-21" @default.
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- W2912387720 date "2019-02-14" @default.
- W2912387720 modified "2023-10-10" @default.
- W2912387720 title "Mobile platform for rapid sub–picogram-per-milliliter, multiplexed, digital droplet detection of proteins" @default.
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- W2912387720 doi "https://doi.org/10.1073/pnas.1814110116" @default.
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