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- W2912387895 endingPage "104166" @default.
- W2912387895 startingPage "104166" @default.
- W2912387895 abstract "The pH in the different tissues and organs of our body is kept within tight limits. Local pH changes occur, however, temporarily under physiological conditions, as for example in synapses during neuronal activity. In pathological situations, such as in ischemia, inflammation, and tumor growth, long-lasting acidification develops. Acid-sensing ion channels (ASICs) are low pH-activated Na+-permeable ion channels that are widely expressed in the central and peripheral nervous systems. ASICs act as pH sensors, leading to neuronal excitation when the pH drops. Animal studies have shown that ASICs are involved in several physiological and pathological processes, such as pain sensation, learning, fear sensing, and neurodegeneration after ischemic stroke. ASIC inhibitors could be used as analgesic and anxiolytic drugs, and as drugs for the treatment of ischemic stroke. For these reasons, ASICs have recently attracted increasing attention. Currently, no drugs are clinically used as ASIC modulators. ASICs are however targets of several peptide toxins from animals. Much effort is invested in research studying the function of these channels. We review here the available pharmacological agents acting on ASICs, which include small molecules and animal toxins. We then discuss the current understanding of the molecular mechanisms by which pH controls ASIC activity. Knowledge of the function of ASICs at the molecular level should allow the development of new pharmacological strategies for targeting these promising ion channels." @default.
- W2912387895 created "2019-02-21" @default.
- W2912387895 creator A5048516955 @default.
- W2912387895 creator A5070454347 @default.
- W2912387895 date "2020-04-01" @default.
- W2912387895 modified "2023-10-11" @default.
- W2912387895 title "A molecular view of the function and pharmacology of acid-sensing ion channels" @default.
- W2912387895 cites W1479889874 @default.
- W2912387895 cites W1528778201 @default.
- W2912387895 cites W1529469224 @default.
- W2912387895 cites W1546862061 @default.
- W2912387895 cites W1827209814 @default.
- W2912387895 cites W1964992329 @default.
- W2912387895 cites W1967376368 @default.
- W2912387895 cites W1974548955 @default.
- W2912387895 cites W1974642350 @default.
- W2912387895 cites W1974801463 @default.
- W2912387895 cites W1982773582 @default.
- W2912387895 cites W1983904542 @default.
- W2912387895 cites W1992767102 @default.
- W2912387895 cites W1993658457 @default.
- W2912387895 cites W1998564418 @default.
- W2912387895 cites W2000269456 @default.
- W2912387895 cites W2001646873 @default.
- W2912387895 cites W2004813038 @default.
- W2912387895 cites W2005960433 @default.
- W2912387895 cites W2006294085 @default.
- W2912387895 cites W2007573099 @default.
- W2912387895 cites W2009495224 @default.
- W2912387895 cites W2011240126 @default.
- W2912387895 cites W2011275944 @default.
- W2912387895 cites W2012095769 @default.
- W2912387895 cites W2013711061 @default.
- W2912387895 cites W2014299900 @default.
- W2912387895 cites W2014671181 @default.
- W2912387895 cites W2015725815 @default.
- W2912387895 cites W2015971228 @default.
- W2912387895 cites W2016772559 @default.
- W2912387895 cites W2019606951 @default.
- W2912387895 cites W2022128427 @default.
- W2912387895 cites W2025537889 @default.
- W2912387895 cites W2027089076 @default.
- W2912387895 cites W2027847248 @default.
- W2912387895 cites W2028297619 @default.
- W2912387895 cites W2032558774 @default.
- W2912387895 cites W2037341321 @default.
- W2912387895 cites W2037738826 @default.
- W2912387895 cites W2043285468 @default.
- W2912387895 cites W2045265824 @default.
- W2912387895 cites W2045646095 @default.
- W2912387895 cites W2047283239 @default.
- W2912387895 cites W2051237359 @default.
- W2912387895 cites W2051746917 @default.
- W2912387895 cites W2054866068 @default.
- W2912387895 cites W2056030494 @default.
- W2912387895 cites W2057012241 @default.
- W2912387895 cites W2058144420 @default.
- W2912387895 cites W2066442803 @default.
- W2912387895 cites W2070334729 @default.
- W2912387895 cites W2071364551 @default.
- W2912387895 cites W2073176414 @default.
- W2912387895 cites W2075334599 @default.
- W2912387895 cites W2076864143 @default.
- W2912387895 cites W2078428052 @default.
- W2912387895 cites W2079612042 @default.
- W2912387895 cites W2079778786 @default.
- W2912387895 cites W2081317765 @default.
- W2912387895 cites W2085805107 @default.
- W2912387895 cites W2086688096 @default.
- W2912387895 cites W2087499467 @default.
- W2912387895 cites W2088993845 @default.
- W2912387895 cites W2090117730 @default.
- W2912387895 cites W2093117429 @default.
- W2912387895 cites W2093896324 @default.
- W2912387895 cites W2096043604 @default.
- W2912387895 cites W2096293984 @default.
- W2912387895 cites W2104984002 @default.
- W2912387895 cites W2107701554 @default.
- W2912387895 cites W2107988902 @default.
- W2912387895 cites W2112886876 @default.
- W2912387895 cites W2118307790 @default.
- W2912387895 cites W2123332169 @default.
- W2912387895 cites W2137678794 @default.
- W2912387895 cites W2138123632 @default.
- W2912387895 cites W2148660598 @default.
- W2912387895 cites W2153523096 @default.
- W2912387895 cites W2161806982 @default.
- W2912387895 cites W2170521339 @default.
- W2912387895 cites W2262750635 @default.
- W2912387895 cites W2508097989 @default.
- W2912387895 cites W2597579173 @default.
- W2912387895 cites W2601581920 @default.
- W2912387895 cites W2603933399 @default.
- W2912387895 cites W2606631328 @default.
- W2912387895 cites W2764115850 @default.
- W2912387895 cites W2768279164 @default.
- W2912387895 cites W2789792412 @default.
- W2912387895 cites W2793059925 @default.