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- W2912388594 abstract "Non-Allergic Rhinitis (NAR) has been estimated to affect 17 million Americans annually. Few therapeutic studies have been conducted on well-characterized patients with NAR. Alternative therapies have been proposed but have ineffective for the treatment of NAR conditions. Studies have demonstrated topical capsaicin is effective at reducing nasal congestion and discharge in allergic and NAR. The aim of this work was to further assess the onset of action and benefits of capsaicin in NAR. A total of 46 subjects with NAR and negative skin prick test were enrolled in this study. Subjects received capsaicin or placebo (23 per arm) 1-2 sprays/nostril twice daily to maximum of 8 total sprays/day for 14 days. Subjects recorded their instantaneous and reflective nasal symptoms (TNSS) using an electronic diary (ePDAT®). Time of first relief of symptoms were measured by patients using a stopwatch. TNSS significantly improved from as early as 10 minutes post dosing in the capsaicin treatment group versus placebo. This improvement was sustainable until 60 minute time-point. It was observed that the majority of subjects treated with capsaicin (12/23) 52.2%, showed relief under one minute and (17/23) 74.0% of patients showed relief for all the symptoms under 2 minutes from time of first-dosing. Capsaicin Nasal Spray showed significant rapid and sustainable relief in overall composite symptom scores of TNSS. The Nasal Spray was generally well-tolerated and there were no safety concerns raised during the study. This finding corroborates and confirms the nasal symptom results from a previous study with the same product." @default.
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- W2912388594 date "2019-02-01" @default.
- W2912388594 modified "2023-09-26" @default.
- W2912388594 title "Capsaicin Nasal Spray Showed Significant And Rapid Relief In All Nasal Symptoms In Subjects With Non-Allergic Rhinitis" @default.
- W2912388594 doi "https://doi.org/10.1016/j.jaci.2018.12.193" @default.
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