Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912388882> ?p ?o ?g. }
- W2912388882 endingPage "268" @default.
- W2912388882 startingPage "259" @default.
- W2912388882 abstract "In adult cardiomyocytes, T-tubules, junctional sarcoplasmic reticulum (jSR), and mitochondria juxtapose each other and form a unique and highly repetitive functional structure along the cell. The close apposition between jSR and mitochondria creates high Ca2+ microdomains at the contact sites, increasing the efficiency of the excitation-contraction-bioenergetics coupling, where the Ca2+ transfer from SR to mitochondria plays a critical role. The SR-mitochondria contacts are established through protein tethers, with mitofusin 2 the most studied SR-mitochondrial “bridge”, albeit controversial. Mitochondrial Ca2+ uptake is further optimized with the mitochondrial Ca2+ uniporter preferentially localized in the jSR-mitochondria contact sites and the mitochondrial Na+/Ca2+ exchanger localized away from these sites. Despite all these unique features facilitating the privileged transport of Ca2+ from SR to mitochondria in adult cardiomyocytes, the question remains whether mitochondrial Ca2+ concentrations oscillate in synchronicity with cytosolic Ca2+ transients during heartbeats. Proper Ca2+ transfer controls not only the process of mitochondrial bioenergetics, but also of mitochondria-mediated cell death, autophagy/mitophagy, mitochondrial fusion/fission dynamics, reactive oxygen species generation, and redox signaling, among others. Our review focuses specifically on Ca2+ signaling between SR and mitochondria in adult cardiomyocytes. We discuss the physiological and pathological implications of this SR-mitochondrial Ca2+ signaling, research gaps, and future trends." @default.
- W2912388882 created "2019-02-21" @default.
- W2912388882 creator A5007425498 @default.
- W2912388882 creator A5045005778 @default.
- W2912388882 date "2019-03-01" @default.
- W2912388882 modified "2023-10-14" @default.
- W2912388882 title "SR-mitochondria communication in adult cardiomyocytes: A close relationship where the Ca2+ has a lot to say" @default.
- W2912388882 cites W139770000 @default.
- W2912388882 cites W1500939659 @default.
- W2912388882 cites W150246076 @default.
- W2912388882 cites W1522450427 @default.
- W2912388882 cites W1523821352 @default.
- W2912388882 cites W1547216871 @default.
- W2912388882 cites W1622243645 @default.
- W2912388882 cites W1934698969 @default.
- W2912388882 cites W1964430604 @default.
- W2912388882 cites W1972621040 @default.
- W2912388882 cites W1972718661 @default.
- W2912388882 cites W1973895988 @default.
- W2912388882 cites W1981049765 @default.
- W2912388882 cites W1981762416 @default.
- W2912388882 cites W1983492852 @default.
- W2912388882 cites W1983700507 @default.
- W2912388882 cites W1986213783 @default.
- W2912388882 cites W1986560775 @default.
- W2912388882 cites W1987553738 @default.
- W2912388882 cites W1987845572 @default.
- W2912388882 cites W1989540421 @default.
- W2912388882 cites W1993851979 @default.
- W2912388882 cites W1994504925 @default.
- W2912388882 cites W1997366047 @default.
- W2912388882 cites W2002439304 @default.
- W2912388882 cites W2002636936 @default.
- W2912388882 cites W2002791298 @default.
- W2912388882 cites W2005641666 @default.
- W2912388882 cites W2005869317 @default.
- W2912388882 cites W2005945017 @default.
- W2912388882 cites W2009024440 @default.
- W2912388882 cites W2015154923 @default.
- W2912388882 cites W2016543067 @default.
- W2912388882 cites W2017567300 @default.
- W2912388882 cites W2018776448 @default.
- W2912388882 cites W2023758830 @default.
- W2912388882 cites W2026731864 @default.
- W2912388882 cites W2028620319 @default.
- W2912388882 cites W2028818658 @default.
- W2912388882 cites W2030405841 @default.
- W2912388882 cites W2030558652 @default.
- W2912388882 cites W2037676584 @default.
- W2912388882 cites W2038197815 @default.
- W2912388882 cites W2040327999 @default.
- W2912388882 cites W2044929466 @default.
- W2912388882 cites W2044963576 @default.
- W2912388882 cites W2045504893 @default.
- W2912388882 cites W2045870786 @default.
- W2912388882 cites W2046196975 @default.
- W2912388882 cites W2046353863 @default.
- W2912388882 cites W2048995238 @default.
- W2912388882 cites W2050824263 @default.
- W2912388882 cites W2052136666 @default.
- W2912388882 cites W2052471341 @default.
- W2912388882 cites W2054451338 @default.
- W2912388882 cites W2054565215 @default.
- W2912388882 cites W2056145463 @default.
- W2912388882 cites W2056982707 @default.
- W2912388882 cites W2058153670 @default.
- W2912388882 cites W2063830130 @default.
- W2912388882 cites W2065383397 @default.
- W2912388882 cites W2065569764 @default.
- W2912388882 cites W2066088939 @default.
- W2912388882 cites W2067340511 @default.
- W2912388882 cites W2067841051 @default.
- W2912388882 cites W2070869619 @default.
- W2912388882 cites W2078132151 @default.
- W2912388882 cites W2078179312 @default.
- W2912388882 cites W2079935073 @default.
- W2912388882 cites W2080355869 @default.
- W2912388882 cites W2084824261 @default.
- W2912388882 cites W2086675887 @default.
- W2912388882 cites W2089090200 @default.
- W2912388882 cites W2089397344 @default.
- W2912388882 cites W2089849293 @default.
- W2912388882 cites W2092510248 @default.
- W2912388882 cites W2092924768 @default.
- W2912388882 cites W2095853126 @default.
- W2912388882 cites W2096579721 @default.
- W2912388882 cites W2101300328 @default.
- W2912388882 cites W2101869143 @default.
- W2912388882 cites W2104048407 @default.
- W2912388882 cites W2107030671 @default.
- W2912388882 cites W2107639321 @default.
- W2912388882 cites W2108539111 @default.
- W2912388882 cites W2115944704 @default.
- W2912388882 cites W2117692658 @default.
- W2912388882 cites W2119900852 @default.
- W2912388882 cites W2121330845 @default.
- W2912388882 cites W2122341467 @default.
- W2912388882 cites W2129495353 @default.