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- W2912392165 abstract "RATIONALE: It would be very important to establish skin prick test (SPT) and specific-IgE antibodies cut-off points to predict a positive challenge test in egg allergy. METHODS: Objective: evaluation of SPT and specific-IgE to egg allergens (white and yolk fractions, ovalbumin (OVA), ovomucoid (OVM), ovotransferrine (OVT) and lisozime) as predictors of tolerance. A transversal study including children with IgE mediated egg allergy. After a year of an egg-excluding-diet we realised a medical history, SPT and specific-IgE antibodies were quantified for egg allergens and a double-blind, placebo-controlled food challenge (DBPCFC). RESULTS: 157 children were included. DBPCFC was positive in 100 (63,7%). Specific- IgE and SPT were analized with the ROC curve. White egg SPT and OVM, and specific-IgE to white egg, OVA and OVM had the biggest areas under the curve, without statistical differences between them.According to regression modelling the final model included white egg SPT and OVM specific-IgE (p<0,05), with OR to positive DBPCFC for white egg SPT 1,32 (1,14-1,54) and for OVM specific-IgE 4,669 (1,23-17,65).A combination of the bests cut-off values of these two tests (obtained with the ROC curves) was explored and the next likelihood ratios (CI 95%) were obtained: -White egg SPT>36mm2 + OVM IgE>0,35 KU/l: 7,96 (2,62-24,22) -White egg SPT<36 mm2 + OVM IgE<0,35 KU/l: 0,19 (0,10-0,34) CONCLUSIONS: White egg SPT and the OVM specific-IgE could be the best tests to predict the result of the challenge test in children allergic to egg. It wouldn't be usefull to determine SPT and specific-IgE to OVT and lisozime in all egg allergic children." @default.
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- W2912392165 date "2006-02-01" @default.
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- W2912392165 title "Validity of Diagnostic Tests in Egg Allergy" @default.
- W2912392165 doi "https://doi.org/10.1016/j.jaci.2005.12.166" @default.
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