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- W2912393385 abstract "ABSTRACTBackground and Aim: Acute lymphoblastic leukemia is the most common cancer in childrenand juveniles and is also seen in adults with lower frequency. Autophagy is a programmedcatabolic process of the cell for destruction of damaged organs and proteins which is carriedout by lysozymes. Disruption of autophagy leads to abnormalities in cellular processesassociated with cancer.Materials and Methods: In this study, we compared the expression of Beclin 1 and Atg 10genes between 50 patients with B-ALL and 18 healthy subjects as our control group, by usingRNA extraction and cDNA synthesis, and RT-PCR method. Data were analyzed by statisticaltests.Results: The majority of B-ALL patients showed a significant reduction in the Beclin1 andAtg 10 genes compared to control group (P <0.05) and the mean expression of the genes (2-∆Ct ± SD) were 0.10 ± 0.49 and 1.01 ± 0.27 for ALL patients and control group and 0.15±0.44and 1.07±0.85 for Atg10 and Beclin1 respectively. There was no significant correlationbetween expression levels of Beclin1and Atg10 in these patients (r =-0.013, P =0.926).Conclusion: Considering the reduced expression levels in the essential genes of autophagy inALL patients in our study and also other studies in this field, disruption of autophagy may beinvolved in leukomogensis" @default.
- W2912393385 created "2019-02-21" @default.
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- W2912393385 date "2019-02-01" @default.
- W2912393385 modified "2023-10-14" @default.
- W2912393385 title "Evaluation of Beclin 1 and Atg10 gene expression of the autophagy pathwayin acute lymphoblastic leukemia patients" @default.
- W2912393385 hasPublicationYear "2019" @default.
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