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• W2912394489 abstract "Zinc oxide nanoparticles (ZnO-NPs) synthesized through biological method has gained significant importance due to its wide range of applications. In the current study, hexagonal wurtzite shaped nanoparticles were biosynthesized using the aqueous leaf extract of Justicia wynaadensis for the first time. The bio-synthesized ZnO-NPs showed an absorption peak at 329 nm which is the characteristic feature of ZnO-NPs. The biosynthesized nanoparticles were of high purity with an average size of ∼39 nm. The SEM images further confirmed the same with agglomeration of nanoparticles. The Fourier Transform Infrared Spectroscopy (FT-IR) confirmed that the metabolites of plant extract were capped during the bio-synthesis process of nanoparticles. The results of antimitotic activity confirmed that, the biosynthesized ZnO-NPs effectively inhibits the cell division from 100 μg mL−1 to 500 μg mL−1. The interaction between CT-DNA and biosynthesized ZnO-NPs showed a hyperchromic shift in absorbance thereby indicating that the DNA structure was changed after addition of ZnO-NPs through intercalate mode. The results validate that the biosynthesized ZnO-NPs form Justicia wynaadensis possess biological activities." @default.
• W2912394489 created "2019-02-21" @default.
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• W2912394489 date "2019-03-01" @default.
• W2912394489 modified "2023-10-02" @default.
• W2912394489 title "Antimitotic and DNA-binding potential of biosynthesized ZnO-NPs from leaf extract of Justicia wynaadensis (Nees) Heyne - A medicinal herb" @default.
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• W2912394489 doi "https://doi.org/10.1016/j.bcab.2019.101024" @default.
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