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- W2912394781 endingPage "105" @default.
- W2912394781 startingPage "105" @default.
- W2912394781 abstract "The etiology of Parkinson’s disease (PD) is significantly influenced by disease-causing changes in the protein alpha-Synuclein (aSyn). It can trigger and promote intracellular stress and thereby impair the function of dopaminergic neurons. However, these damage mechanisms do not only extend to neuronal cells, but also affect most glial cell populations, such as astroglia and microglia, but also T lymphocytes, which can no longer maintain the homeostatic CNS milieu because they produce neuroinflammatory responses to aSyn pathology. Through precise neuropathological examination, molecular characterization of biomaterials, and the use of PET technology, it has been clearly demonstrated that neuroinflammation is involved in human PD. In this review, we provide an in-depth overview of the pathomechanisms that aSyn elicits in models of disease and focus on the affected glial cell and lymphocyte populations and their interaction with pathogenic aSyn species. The interplay between aSyn and glial cells is analyzed both in the basic research setting and in the context of human neuropathology. Ultimately, a strong rationale builds up to therapeutically reduce the burden of pathological aSyn in the CNS. The current antibody-based approaches to lower the amount of aSyn and thereby alleviate neuroinflammatory responses is finally discussed as novel therapeutic strategies for PD." @default.
- W2912394781 created "2019-02-21" @default.
- W2912394781 creator A5011568482 @default.
- W2912394781 creator A5019577228 @default.
- W2912394781 creator A5023179906 @default.
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- W2912394781 creator A5028943503 @default.
- W2912394781 creator A5048745413 @default.
- W2912394781 creator A5062220148 @default.
- W2912394781 creator A5073997580 @default.
- W2912394781 date "2019-01-31" @default.
- W2912394781 modified "2023-10-13" @default.
- W2912394781 title "Novel Immunotherapeutic Approaches to Target Alpha-Synuclein and Related Neuroinflammation in Parkinson’s Disease" @default.
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